Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Monocyte Expression of Toll-like Receptor-4 in Patients with Stable Angina Undergoing Percutanoeus Coronary Intervention

Bahador Bagheri; Bahram Sohrabi; Aliakbar Movassaghpur; Siminozar Mashayekhi; Afagh Garjani; Mehriar Shokri; Mohammad Noori; Alireza Garjani

Volume 9, Issue 3 , September 2012, , Pages 149-158

Abstract
  Background: Toll like receptors (TLRs) are well recognized players in inflammatory conditions. Among them TLR-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. Objective: The present study was aimed to examine the effects of percutanoeus coronary intervention ...  Read More

The Predictive Value of HLA-DR Matching and Cytokine Gene Polymorphisms in Renal Allograft Acute Rejection: A Living-unrelated Donor (LURD) Study

Nader Tajik; Tohid Kazemi; Aliakbar Delbandi; Ahad Ghods; Alireza Salek Moghaddam

Volume 3, Issue 4 , December 2006, , Pages 150-156

Abstract
  Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated ...  Read More

Translational Insights on Lung Transplantation: Learning from Immunology

Mohamed Shehata Ali Mohamed

Volume 12, Issue 3 , September 2015, , Pages 156-165

Abstract
  The introduction of ex vivo lung perfusion (EVLP) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. In addition, EVLP can provide a platform for the application of various preventive measures to decrease the ...  Read More

Immunogenicity of a New HIV-1 DNA Construct in a BALB/c Mouse Model

Mehdi Mahdavi; Masoumeh Ebtekar; Fereidoun Mahboudi; Hamidreza Korram Khorshid; Fatemeh Rahbarizadeh; Kayhan Azadmanesh; Haydeh Darabi; Farzaneh Pourasgari; Zuhair Mohammad Hassan

Volume 6, Issue 4 , December 2009, , Pages 163-173

Abstract
  Background: Cell mediated immunity, especially cytotoxic T cell responses against HIV-1 infection, plays a critical role in controlling viral replication and disease progres-sion. DNA vaccine is a novel technology which is known to stimulate strong cellular immune responses. Many DNA vaccines have been ...  Read More

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Xiaoying Wang; Keye Xu; Sisi Chen; Yan Li; Mingcai Li

Volume 15, Issue 3 , September 2018, , Pages 165-174

https://doi.org/10.22034/iji.2018.39386

Abstract
  Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell ...  Read More

The Cerebrospinal Fluid Presentations of Neuro-Bechet Disease, a Way to Know ‎the Etiopathogenesis and Improve Armamentarium‎

Shubhasree Banerjee; Kamel Hamzaoui; Anahid Safari; Afshin Borhani-Haghighi

Volume 18, Issue 3 , September 2021, , Pages 170-178

https://doi.org/10.22034/iji.2021.47855

Abstract
  Neuro-Behcet's disease (NBD) is a rare but potentially fatal manifestation of Behcet's disease. Common presentations of neuro-Behcet's disease are parenchymal (brainstem and hemispheric manifestations, meningoencephalitis, spinal cord lesions) and non-parenchymal (arterial occlusions, aneurysms, Dural ...  Read More

Antitumor Response to a Codon-Optimized HPV-16 E7/HSP70 Fusion Antigen DNA Vaccine

Hoorieh Soleimanjahi; Hadi Razavinikoo; Fatemeh Fotouhi; Abdollah Ardebili

Volume 14, Issue 3 , September 2017, , Pages 180-191

Abstract
  Background: Vaccines based on virus-like particles are effective against Human Papilloma Virus (HPV) infection; however, they have not shown a therapeutic effect against HPV-associated diseases. New immunotherapy strategies based on immune responses against tumor antigens can positively affect the clearance ...  Read More

Over-expression of Wilm’s Tumor Gene 1 (WT1) in Iranian Patients with Acute Myeloblastic Leukemia

Hossein Asgarian; Mahdi Shabani; Parvaneh Vosoogh; Ramazan Ali Sharifian; Soheila Gharagozlou; Jalal Khoshnoodi; Tahereh Shahrestani; Mahin Kordmahin; Abdolfattah Sarrafnejad; Mahmood Jeddi Tehrani; Hodjatallah Rabbani; Fazel Shokri

Volume 2, Issue 4 , December 2005, , Pages 182-190

Abstract
  Background: The Wilm’s tumor gene 1 (WT1) encodes a zinc finger transcription factor that is inactivated in a subset of Wilm’s tumors. It plays a crucial role in growth, proliferation and development of some embryonic and adult organs. WT1 is expressed as a tumor associated antigen (TAA) ...  Read More

Vaccination against Mosquito Borne Viral Infections: Current Status

Viroj Wiwanitkit

Volume 4, Issue 4 , December 2007, , Pages 186-196

Abstract
  Mosquito borne infectious diseases are among important group of diseases worldwide. Vaccination is available for some tropical mosquito-borne diseases, especially for Japa-nese encephalitis virus infection and yellow fever. There are also several attempts to develop new vaccines for the other mosquito-borne ...  Read More

Immunologic Basis and Immunoprophy-laxis of RhD Induced Hemolytic Disease of the Newborn (HDN)

Roya Payam Khaja Pasha; Fazel Shokri

Volume 5, Issue 4 , December 2008, , Pages 189-200

Abstract
  RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN ...  Read More

Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages

Enna Liu; Zheng Li; Yan Zhang; Kuisheng Chen

Volume 16, Issue 3 , September 2019, , Pages 190-199

https://doi.org/10.22034/iji.2019.80270

Abstract
  Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions. Although hepcidin has been shown to affect ferroportin expression in macrophages, whether it affects macrophage polarization is still ...  Read More

IL-17 and IL-4 Producing CD8+ T Cells in Tumor Draining Lymph Nodes of Breast Cancer Patients: Positive Association with Tumor Progression

Zahra Faghih; Somayeh Rezaeifard; Akbar Safaei; Abbas Ghaderi; Nasrollah Erfani

Volume 10, Issue 4 , December 2013, , Pages 193-204

Abstract
  Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: ...  Read More

Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion

Mohammad Ali Ghayumi; Zahra Mojtahedi; Mohammad Javad Fattahi

Volume 8, Issue 4 , December 2011, , Pages 195-200

Abstract
  Background: The alteration of Th1 and Th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a Th2 immune response. Objective: To examine the different levels of IL-4 and IL-10 (Th2 cytokines), and IL-2 and interferon-γ (IFN-γ) ...  Read More

An Endogenous Immune Adjuvant Released by Necrotic Cells for Enhancement of DNA Vaccine Potency

Rohollah Dorostkar; Taravat Bamdad; Masoud Parsania; Hassan Pouriayevali

Volume 9, Issue 4 , December 2012, , Pages 215-225

Abstract
  Background: Improving vaccine potency in the induction of a strong cell-mediated cytotoxicity can enhance the efficacy of vaccines. Necrotic cells and the supernatant of necrotic tumor cells are attractive adjuvants, on account of their ability to recruit antigen-presenting cells to the site of antigen ...  Read More

Reference Values of Lymphocyte Sub-Populations in Healthy Human Immunodeficiency Virus-Negative Iranian Adults

Atefeh Kamallou; Mahbobeh Haji Abdolbaghi; Minoo Mohraz; Mernaz Rasolinejad; Ehsan Karbasi; Bita Ansaripour; Samaneh Soltani; Arezou Rezaei; Neda Khalili; Aliakbar Amirzargar

Volume 11, Issue 4 , December 2014, , Pages 221-232

Abstract
  Background: Lymphocyte subsets enumeration is considered prominent in the management of primary and acquired immunodeficiency disorders. Because of local variations due to race, age, gender, and environmental conditions on lymphocyte subsets, and to improve the accuracy of interpretation of laboratory ...  Read More

Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs

Ladan Langroudi; Zuhair Muhammad Hassan; Masoud Soleimani; Seyed Mahmoud Hashemi

Volume 12, Issue 4 , December 2015, , Pages 226-239

Abstract
  Background: Differentiation, migratory properties and availability of Mesenchymal Stromal Cells (MSC) have become an important part of biomedical research. However, the functional heterogeneity of cells derived from different tissues has hampered providing definitive phenotypic markers for these cells. ...  Read More

CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes

Zahra Faghih; Saeideh Sadat Shobeiri; Ali Ariafar; Mohsen Sarkarian; Shahryar Zeighami; Nazanin Nazari; Saeed Abbasi-Sarvak; Nasrollah Erfani

Volume 13, Issue 4 , December 2016, , Pages 237-248

Abstract
  Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor ...  Read More

DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System

Ahmad Mobed

Volume 17, Issue 4 , December 2020, , Pages 255-274

https://doi.org/10.22034/iji.2020.87480.1806

Abstract
  Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB. Despite the protective effect of this vaccine in children, its efficiency remains under question in adults. We conducted ...  Read More

CD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia

Esmaeil Allahmoradi; Saeid Taghiloo; Mohsen Tehrani; Hadi Hossein-Nattaj; Ghasem Janbabaei; Ramin Shekarriz; Hossein Asgarian-Omran

Volume 14, Issue 4 , December 2017, , Pages 257-269

Abstract
  Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized ...  Read More

Effects of Dendritic Cell Vaccine Activated with Components of Lieshmania Major on Tumor Specific Response

Samaneh Arab; Masoumeh Motamedi; Jamshid Hadjati

Volume 16, Issue 4 , December 2019, , Pages 268-277

https://doi.org/10.22034/iji.2019.80278

Abstract
  Background: Dendritic cells (DCs) contribute essentially to the outset and course of immune responses. So in patients with malignancy, there have been considerable interests in use of these cells in different interventions. Objective: To evaluate the impact of Leishmania major’s components ...  Read More

Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips

Ali Shams; Sahar Khosravi; Aysan Zareiye; Yeganeh Lalehzari; Reyhane Nematollahi; Solmaz Basti

Volume 20, Issue 4 , December 2023, , Pages 382-399

https://doi.org/10.22034/iji.2023.98326.2567

Abstract
  Cell-mediated immunity (CMI) is crucial in controlling the highly aggressive and progressive SARS-CoV-2 infection. Despite extensive researches on severe COVID-19 infection, the etiology and/or mechanisms of lymphopenia, decreased T cell-mediated responses in patients, cytokine release storms (CRS), ...  Read More

KIR2DS3 is Associated with Protection against Acute Myeloid Leukemia

Farhad Shahsavar; Nader Tajik; Kobra-Zinat Entezami; Masoomeh Fallah Radjabzadeh; Behnam Asadifar; Kamran Alimoghaddam; Mohammadreza Ostadali Dahaghi; Arash Jalali; Andisheh Ghashghaie; Ardeshir Ghavamzadeh

Volume 7, Issue 1 , March 2010, , Pages 8-17

Abstract
  Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility ...  Read More

T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors

Bijan Khademi; Marziyeh Tajvarpour; Zahra Mojtahedi; Mohammad Reza Haghshenas; Nasrollah Erfani

Volume 13, Issue 1 , March 2016, , Pages 9-15

Abstract
  Background: Salivary gland tumors are among malignancies that have high recurrence rate. Immune responses in salivary gland tumors have not been well elucidated. T helper type 1 (Th1) and Th2 cytokines have been reported to play a role in the outcome of head and neck cancers. Objective: To evaluate the ...  Read More

Evaluation of CD64 Expression on Peripheral Blood Neutrophils for Early Detection of Neonatal Sepsis

Minoo Adib; Fakhri Navaei; Farzad Oreizi; Fereshteh Saheb-Fosoul; Vajiheh Ostadi

Volume 3, Issue 1 , March 2006, , Pages 9-14

Abstract
  Background: Neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. The clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. Objective: The aim of this study ...  Read More