Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Evaluation of CD4+/CD25+/high/CD127low/- Regulatory T Cells in Rheumatoid Arthritis Patients

Samaneh Delavari; Mehri Ghafourian; Elham Rajaei; Karim Mowla; Ata Ghadiri

Volume 18, Issue 3 , September 2021, , Pages 179-187

https://doi.org/10.22034/iji.2021.68100.1365

Abstract
  Background: Rheumatoid arthritis (RA) is the most common rheumatoid disease of unknown etiology, determined by the articular cartilage destruction and bone loss. The hallmark of RA is the defect in immune tolerance. Regulatory T cells (Treg) play a critical role in the protection of peripheral tolerance. ...  Read More

Serum Level of HER-2 Extracellular Domain in Iranian Patients with Breast Cancer: A Follow-up Study

Mehrnoosh Doroudchi; Abdolrasoul Talei; Helmout Modjtahedi; Alamtaj Samsami Dehaghani; Abdol Mohammad Pezeshki; Hilary Thomas; Abbas Ghaderi

Volume 2, Issue 4 , December 2005, , Pages 191-200

Abstract
  Background: A soluble form of HER-2/neu extracellular domain (sHER-2) is reported to be released in the sera of metastatic breast cancer patients. Objective: To measure the level of sHER-2 in sera of 115 breast cancer patients. Methods: Serial samples of 27 patients with metastasis, 18 non-metastatic ...  Read More

Rapamycin Inhibits Expansion of Cord Blood Derived NK and T Cell

Monireh Zare; Behnaz Valipour; Seyede Momeneh Mohammadi; Mohammad Nouri; Aliakbar Movassaghpour; Hojjatollah Nozad Charoudeh

Volume 14, Issue 3 , September 2017, , Pages 192-199

Abstract
  Background: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. Objectives: To evaluate the effect of mTOR inhibition, ...  Read More

Increased Expression of TRAIL and Its Receptors on Peripheral T-Cells in Type 1 Diabetic Patients

Eisa Salehi; Mohammad Vodjgani; Ahmad massoud; Abdolhosein Keyhani; Asadollah Rajab; Behrooz Shafaghi; Zahra Gheflati; Tahereh Aboufazeli

Volume 4, Issue 4 , December 2007, , Pages 197-205

Abstract
  Background: Type-I diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. TNF-related apoptosis-inducing ligand (TRAIL) is a type-II membrane protein of the TNF superfamily which is expressed in different tissues, including pancreas ...  Read More

Immunogenic Evaluation of Bivalent Vaccine Candidate against Enterohemorrhagic and Enterotoxigenic Escherichia coli

Ahmad Karimi Rahjerdi; Mahyat Jafari; Mohammad Javad Motamedi; Jafar Amani; Ali Hatef Salmanian

Volume 16, Issue 3 , September 2019, , Pages 200-211

https://doi.org/10.22034/iji.2019.80271

Abstract
  Background: Caused by bacterial, viral, and parasitic pathogens, diarrhea is the second leading cause of death among children under five. Two strains of E. coli, namely Enterotoxigenic, ETEC and Enterohemorrhagic EHEC are the most important causes of this disease in developing countries. EHEC is a major ...  Read More

Cytokine Profile in the Endometrium of Normal Fertile and Women with Repeated Implantation Failure

Samira Rajaei; Amir Hassan Zamani; Mahmood Jeddi-Tehrani; Maryam Tavakoli; Afsaneh Mohammadzadeh; Ali Dabbagh; Mahroo Mirahmadian

Volume 8, Issue 4 , December 2011, , Pages 201-208

Abstract
  Background: Repeated Implantation Failure (RIF) is one of the most intricate obstacles in assisted reproduction. The cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. Objective: To compare the cytokine profile in the endometrium of normal fertile ...  Read More

Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival

Mir Davood Omrani; Mohammad Reza Mokhtari; Ali Tagizadae; Morteza Bagheri; Pedram Ahmad-Poor

Volume 5, Issue 4 , December 2008, , Pages 201-206

Abstract
  Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of ...  Read More

Quantiation of IL-4, IL-10 and IFN- Genes Expression after Immunization of Mice with CFP-10 and ESAT-6 Containing Vectors

Azam Torabi; Mojtaba Tahmoorespur; Fatemeh Vahedi; Nader Mosavari; Mohammadreza Nassiri

Volume 10, Issue 4 , December 2013, , Pages 205-215

Abstract
  Background: Tuberculosis is a disease with high morbidity, caused mainly by Mycobaterium tuberculosis (M.tb.). DNA vaccines show a promising future due to their unique advantages over conventional methods. The early-secreted antigen target (ESAT)-6 and culture filtrate protein (CFP)-10 of M.tb. antigens ...  Read More

The Effect of Cationic Liposomes Encapsulating pcDNA3.1+PA Plasmids on Humoral Immune Response in Mice

Fatemeh Vahedi; Mahmoud Reza Jaafari; Mahmoud Mahmoudi

Volume 7, Issue 4 , December 2010, , Pages 210-216

Abstract
  Background: DNA vaccines are third generation vaccines which have made promises to combat infectious diseases. Cationic liposomes are used as effective delivery systems for DNA vaccines to generate stronger immunity. Objective: Encapsulation of pcDNA3.1+PA plasmid, encoding protective antigen (PA) of ...  Read More

CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population

Nasrollah Erfani; Faezeh Moghaddasi-Sani; Mahboubeh Razmkhah; Mohammad Reza Haghshenas; Abdolrasoul Talaei; Abbas Ghaderi

Volume 9, Issue 4 , December 2012, , Pages 226-233

Abstract
  Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known ...  Read More

Differences in the Expression of TLRs and Inflammatory Cytokines in Pre-Eclamptic Compared with Healthy Pregnant Women

Feryal Dabagh-Gorjani; Fahimeh Anvari; Jaleh Zolghadri; Eskandar KamaliSarvestani; Behrouz Gharesi-Fard

Volume 11, Issue 4 , December 2014, , Pages 233-245

Abstract
  Background: Preeclampsia (PE) is one of the most complex and life-threatening pregnancy disorders and is considered as a major cause of mortality among mothers and fetuses worldwide. Although the exact etiology of PE is not well known several lines of evidence support an immunological etiology for PE. ...  Read More

Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes

Babak Aghili; Ali Akbar Amirzargar; Asadollah Rajab; Ali Rabbani; Arya Sotoudeh; Sara Assadiasl; Bagher Larijani; Ahmad Massoud

Volume 12, Issue 4 , December 2015, , Pages 240-251

Abstract
  Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells ...  Read More

Resting and Activated Natural Tregs Decrease in the Peripheral Blood of Patients with Atherosclerosis

Mohammadreza Yazdani; Shahdad Khosropanah; Ahmad Hosseini; Mehrnoosh Doroudchi

Volume 13, Issue 4 , December 2016, , Pages 249-262

Abstract
  Background: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries. CD4+ T cells are known to play a role in the progression of the disease. CD4+CD25+Foxp3+ natural Treg (nTreg) cells seem to have a protective role in the disease and their reduction in acute coronary ...  Read More

CD40 Knocked Down Tolerogenic Dendritic Cells Decrease Diabetic Injury

Aziz Mahmoudzadeh; Ali Akbar Pourfathollah; Mohammad Hossein Karimi; Seyed Mohammad Moazzeni

Volume 14, Issue 4 , December 2017, , Pages 270-280

Abstract
  Background: Type-1 diabetes (T1D) is an autoimmune disease in which T lymphocytes destroy insulin-producing β-cells. Control of self-reactive T lymphocytes and recovery of diabetic injury is the end point of T1D. Objective: To investigate generation of tolerogenic dendritic cells (tolDCs) as an ...  Read More

Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis

Hong Ouyang; Jie Cheng; Jingdong Du; Huiyun Gan; Zheng Lu

Volume 17, Issue 4 , December 2020, , Pages 275-282

https://doi.org/10.22034/iji.2020.84871.1675

Abstract
  Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR). IL-27, an anti-inflammatory cytokine, has been reported to promote the production of IL-12R and induce Th1 cell responses. ...  Read More

Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells Inhibit CD8+ T Cell Function in a Process that May Implicate Fibroblast Activation Protein α

Yadan Wang; Xiaofei Wu; Yu Hu

Volume 16, Issue 4 , December 2019, , Pages 278-290

https://doi.org/10.22034/iji.2019.80279

Abstract
  Background: Multiple myeloma (MM) is a malignant plasma cell proliferative disorder with limited immunotherapy treatment because of T cell dysfunction. Objective: To investigate the immunomodulatory function of bone marrow mesenchymal stromal cells (MM-BMSCs) on CD8+ T cells. Methods: Proliferation and ...  Read More

Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity

Maryam Nourizadeh; Elham Feizabadi; Milad Mirmoghtadaei; Ashraf Mohammadi; Mohammad Reza Fazlollahi; Leila Moradi; Zahra Pourpak

Volume 20, Issue 4 , December 2023, , Pages 400-409

https://doi.org/10.22034/iji.2023.97759.2525

Abstract
  Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with inborn errors of immunity (IEI).Objective: To evaluate the levels of antibody (Ab) production and function after COVID-19 vaccination in IEI patients with phagocytic, complement, and Ab deficiencies and their comparison ...  Read More

Evaluation of Serum Interleukin-18 levels in Helicobacter Pylori-infected Peptic Ulcer Patients and its Association with Bacterial CagA Virulence Factor

Abdollah Jafarzadeh; Mohammad Ali Sajjadi

Volume 3, Issue 1 , March 2006, , Pages 15-22

Abstract
  Background: Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide. Predominant T-helper 1 (Th1) responses with increased gamma interferon (IFN- γ) levels have been proposed to play an important role in H. pylori-induced peptic ulcer. However, bacterial factors ...  Read More

Interferon β-1a and Atorvastatin in the Treatment of Multiple Sclerosis

Keyvan Ghasami; Fardin Faraji; Masoud Fazeli; Ali Ghazavi; Ghasem Mosayebi

Volume 13, Issue 1 , March 2016, , Pages 16-26

Abstract
  Background: Statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. Objective: To evaluate the effects of atorvastatin in combination with Interferon-β in the treatment of multiple sclerosis (MS) in a randomized controlled ...  Read More

Anti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion

Ghasem Solgi; Gholamreza Pourmand; Abdorasool Mehrsai; Mohsen Tahei-mahmoudi; Mohammad Hossein Nicknam; Mohammad Ebrahimi Rad; Ali Seraji; Amirabbas Asadpoor; Bita Ansaripor; Behrouz Nikbin; Aliakbar Amirzargar

Volume 7, Issue 1 , March 2010, , Pages 18-29

Abstract
  Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion ...  Read More

Effect of Surgical Flap on IL-1β and TGF-β Concentrations in the Gingival Crevicular Fluid of Patients with Moderate to Severe Chronic Periodontitis

Mandana Sattari; Alireza Fathiyeh; Fatemeh Gholami; Hassan Darbandi Tamijani; Mahdi Ghatreh Samani

Volume 8, Issue 1 , March 2011, , Pages 20-26

Abstract
  Background: Growth factors play a major part in wound healing in many tissues including the periodontium. Transforming growth factor-β1 (TGF-β1) is one of these factors present in the gingival crevicular fluid. In addition, it is considered as one of the most important anti-inflammatory cytokines. ...  Read More

Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma

Mahendra Narain Mishra; Puja Dudeja; Rakesh Kumar Gupta

Volume 11, Issue 1 , March 2014, , Pages 21-28

Abstract
  Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population. Objective: To define the HLA-Class II antigens in ...  Read More

Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer

Maryam Hamidinia; Mehri Ghafourian Boroujernia; Abdolhassan Talaiezadeh; Ghasem Solgi; Maryam Taghdiri; Ali Khodadadi

Volume 10, Issue 1 , March 2013, , Pages 22-30

Abstract
  Background: Regulatory T cells (T-regs) have an important role in cancer by suppression of protective antitumor immune responses. Regulatory T cells express the forkhead/winged helix transcription factor (FOXP3) and OX40 molecules which have important regulatory roles in the immune system. Objective: ...  Read More

Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity

Masumeh Gorgian Mohammadi; Taravat Bamdad; Masoud Parsania; Hamid Reza Hashemi; Somayeh Puyanfard

Volume 6, Issue 1 , March 2009, , Pages 22-27

Abstract
  Background: Herpes simplex virus type 1 is one of the most common viruses among human population. Studies demonstrate the essential role of cell mediated immunity, especially CD8+ T cells, in prevention and clearance of HSV1. Objective: It is of great importance to improve our knowledge about the kinetics ...  Read More