Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study

Morteza Hosseinzadeh; Mohsen Nafar; Pedram Ahmadpoor; Farshid Noorbakhsh; Mir Saeed Yekaninejad; Mohammad Hossein Niknam; Aliakbar Amirzargar

Volume 14, Issue 1 , March 2017, , Pages 24-34

Abstract
  Background: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression of TLRs in peripheral blood mononuclear cells ...  Read More

Haussknechtia Elymatica: A Plant with Immunomodulatory Effects

Zahra Amirghofran; Abbas Azadmehr; Katayoun Javidnia

Volume 4, Issue 1 , March 2007, , Pages 26-31

Abstract
  Background: Plant extracts have been widely investigated for possible immunomodu-latory properties. Objective: To study the immunomodulatory functions of the metha-nol extract of Haussknechtia elymatica (Apioideae), an herb native to south-western Iran. Methods: Delayed type hypersensitivity (DTH) skin ...  Read More

Effect of Cytomegalovirus Recombinant Phosphoprotein 150 (pp150) on Function and Maturation of Murine Dendritic Cells: an In-Vitro Study

Yousef Nikmanesh; Shohreh Shahmahmoodi; Ramin Yaghobi; Sayed Mahdi Marashi; Mahmood Mahmoudi; Mahdokht Hossein Aghdaie; Maryam Khosravi; Mohammad Hossein Karimi

Volume 17, Issue 1 , March 2020, , Pages 26-40

https://doi.org/10.22034/iji.2020.80292

Abstract
  Background: Tegument protein pp150 of cytomegaloviruses (CMVs) plays a vital role in all stages of viral life cycle, representing the most important tegument protein candidate for HCMV treatment. However, the exact role of pp150 in immune regulation is yet to be elucidated. Objective: To examine the ...  Read More

Symptomatic Reactivation of HSV Infection Correlates with Decreased Serum Levels of TNF-α

Mohammad Motamedifar; Jamal Sarvari; Azin Ebrahimpour; Amir Emami

Volume 12, Issue 1 , March 2015, , Pages 27-34

Abstract
  Background: Herpes simplex viruses (HSV) are human pathogens that establish lytic and latent infections. Reactivation from latency occurs intermittently, which represents a life-long source for recurrent infection. The role of immune factors in the control of recurrent symptomatic HSV lesions is complex ...  Read More

Prognostic Value of HLA-G in Malignant Liver and Pancreas Lesions

Parisa Khodabandeh Shahraki; Yasmin Zare; Negar Azarpira; Massood Hosseinzadeh; Shirin Farjadian

Volume 15, Issue 1 , March 2018, , Pages 28-37

Abstract
  Background: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. Objective: This study was designed to elucidate the prognostic ...  Read More

The Influence of Perforin Expression on the Sensitivity of LAK/NK Killing Against Various Tumor Target Cells

Zahra Amirghofran

Volume 2, Issue 1 , March 2005, , Pages 29-35

Abstract
  Background: Perforin is known to be important in cytolytic activity mediated by natural killer (NK) cells.   Objective: To study the relationship between the efficiency of NK and lymphokine-activated killer (LAK) cells activity, and the expression of perforin and HLA class I molecules.   Methods: ...  Read More

p53 Protein Expression and Its Relation to the Apoptotic Index in Prostate Adenocarcinoma

Nasser Gholijani; Ahmad Monabati; Zahra Amirghofran

Volume 1, Issue 1 , June 2004, , Pages 34-40

Abstract
  Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer ...  Read More

Listeria Monocytogenes Activated Dendritic Cell Based Vaccine for Prevention of Experimental Tumor in Mice

Masoumeh Khamisabadi; Samaneh Arab; Masoumeh Motamedi; Nematollah khansari; Seied Mohammad Moazzeni; Zahra Gheflati; Jamshid Hadjati

Volume 5, Issue 1 , March 2008, , Pages 36-44

Abstract
  Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose ...  Read More

Association of KIR3DS1+HLA-B Bw4Ile80 Combination with Susceptibility to Tuberculosis in Lur Population of Iran

Farhad Shahsavar; Tahereh Mousavi; Alireza Azargoon; Kobra Entezami

Volume 9, Issue 1 , March 2012, , Pages 39-47

Abstract
  Background: Natural killer (NK) cells are the effector cells of innate immunity that respond to infection and tumor. Interactions between killer cell immunoglobulin like receptors (KIR) and human leukocyte antigen (HLA) class I molecules regulate NK cells responses to eliminate infected and transformed ...  Read More

Anti-streptokinase Antibody Detection before and Immediately after Streptokinase Therapy in Patients with Myocardial Infarction

Hasan Shemirani; Abbas Rezaei

Volume 3, Issue 2 , June 2006, , Pages 66-69

Abstract
  Background: Myocardial infarction (MI) is one of the most common and serious diseases resulting from coronary artery occlusion and major reduction in blood flow. Streptokinase as a thrombolytic is considered the first and most important therapeutic intervention for reperfusion following MI in most countries ...  Read More

Expression of Recombinant Heat-Shock Protein 70 of MCAN/IR/96/LON-49, a Tool for Diagnosis and Future Vaccine Research

Manoochehr Rasouli; Ahmad Zavaran Hoseini; Bahram Karimi; Abdolvahab Alborzi; Simin Kiany

Volume 6, Issue 2 , June 2009, , Pages 75-86

Abstract
  Background: Heat shock protein 70 (HSP70) is present in all organisms studied so far, and is a major immunogen in infections caused by pathogens including Leishmania spp. Objective: The aim of this study was to clone and express HSP70 from L. infantum strain MCAN/IR/96/LON-49 and evaluate antibody response ...  Read More

Interleukin-17 Serum Levels and TLR4 Polymorphisms in Ulcerative Colitis

Mojgan Mohammadi; Mohammad Javad Zahedi; Amin Reza Nikpoor; Mohammad Reza Baneshi; Mohammad Mahdi Hayatbakhsh

Volume 10, Issue 2 , June 2013, , Pages 83-92

Abstract
  Background: Inflammatory bowel disease, an autoimmune disease, has two clinical manifestations including Crohn’s disease and ulcerative colitis (UC). IL-17 has been the target of intensive research in autoimmune diseases. The influence of Toll like receptor 4 (TLR-4) gene polymorphisms on IL-17 ...  Read More

Comparison of Several Maturation Inducing Factors in Dendritic Cell Differentiation

Saeid Abediankenari; Yousef Yousedzadeh; Hossein Azadeh; Mohammad Vahedi

Volume 7, Issue 2 , June 2010, , Pages 83-87

Abstract
  Background: Dendritic cells (DCs) are professional antigen presenting cells that have an important role in the initiation of immune response. The use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. Objective: In this study, we compared tumor necrosis ...  Read More

Increase of CD69, CD161 and CD94 on NK Cells in Women with Recurrent Spontaneous Abortion and in Vitro Fertilization Failure

Mehri Ghafourian; Najmeh Karami; Ali Khodadadi; Roshan Nikbakhat

Volume 11, Issue 2 , June 2014, , Pages 84-96

Abstract
  Background: Recurrent spontaneous abortion (RSA) and in vitro fertilization (IVF) failure with unknown causes are the controversial issues that are probably related to the immune system. Objective: To compare circulating NK cells expressing activation and inhibition surface markers between patients with ...  Read More

HLA-B27 Association with Uveitis in an Asian Indian Population

Mahendra Narin Mishra; Khurshed Minoo Bharucha

Volume 8, Issue 2 , June 2011, , Pages 85-89

Abstract
  Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. Objectives: To establish the frequency of HLA-B27- positive uveitis in Asian Indian population, ...  Read More

HLA class II Genetic Diversity in Arabs and Jews of Iran

Shirin Farjadian; Abbas Ghaderi

Volume 4, Issue 2 , June 2007, , Pages 85-93

Abstract
  Background: Anthropological studies based on highly polymorphic HLA genes pro-vide useful information for bone marrow donor registry, forensic medicine, disease as-sociation studies, as well as designing peptide vaccines against tumors, and infectious or autoimmune diseases. Objective: This study was ...  Read More

Prediction of Rejection in Renal Transplantation by Immune Parameters

Mahboob Lessan-Pezeshki; Ali Akbar Amirzargar; Nooshin Golabi; Mohammadreza Khatami; Behzad Einollahi; Vahid Pourfarziani; Farideh Khosravi; Hassaneh Tajerzadeh; Behrouz Nikbin

Volume 2, Issue 2 , June 2005, , Pages 87-90

Abstract
  Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.   Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic ...  Read More

HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine

Ali Akbar Amirzargar; Nilufar Mohseni; Mohammad Ali Shokrgozar; Zohreh Arjang; Nahid Ahmadi; Manijeh Yousefi Behzadi; Amir Amanzadeh; Fazel Shokri

Volume 5, Issue 2 , June 2008, , Pages 92-99

https://doi.org/10.22034/iji.2008.17105

Abstract
  Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (HLA) class-II alleles or haplotypes. Objectives: ...  Read More

Phenotypic and Functional Comparison between Flask Adherent and Magnetic Activated Cell Sorted Monocytes Derived Dendritic Cells

Nowruz Delirezh; Ehsan Shojaeefar

Volume 9, Issue 2 , June 2012, , Pages 98-108

Abstract
  Background: Generation of an effective dendritic cell (DC) based cancer vaccine depends on appropriate differentiation of monocytes in vitro. Objective: To compare the effects of monocyte separation methods, flask adherence (Flask-DC) and magnetic activated cell sorting (MACS-DC), on phenotypic and functional ...  Read More

Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction

Mahdi Sajedi Khania; Alireza Abdi Ardekan; Shahdad Khosropana; Mehrnoosh Doroudchi

Volume 13, Issue 2 , June 2016, , Pages 100-113

Abstract
  Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries. Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients ...  Read More

Lipopolysaccharide Induced Activation of Toll Like Receptor 4 in Isolated Rat Heart Suggests a Local Immune Response in Myocardium

Maryam Rameshrad; Nasrin Maleki-Dizaji; Haleh Vaez; Hamid Soraya; Ailar Nakhlband; Alireza Garjani

Volume 12, Issue 2 , June 2015, , Pages 104-116

Abstract
  Background: Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. In many cases of sepsis, the presence of Lipopolysaccharide (LPS) has been established. LPS Binding Protein ...  Read More

Immunological Correlates of Adult Onset Idiopathic Generalized Tonic-clonic Epilepsy before and after Sodium Valproate Treatment

Gholamali Yousefi-Pour; Sadegh Izadi; Abbas Ghaderi

Volume 1, Issue 2 , September 2004, , Pages 105-110

Abstract
  Objective: To investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among Iranian patients before and after sodium valproate treatment.   Patients and Methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic ...  Read More

Immunodiagnostic Value of Echinococcus Granulosus Recombinant B8/1 Subunit of Antigen B

Amir Savardashtaki; Bahador Sarkari; Farzane Arianfar; Zohreh Mostafavi-Pour

Volume 14, Issue 2 , June 2017, , Pages 111-122

Abstract
  Background: Cystic echinococcosis (CE), as a chronic parasitic disease, is a major health problem in many countries. The performance of the currently available serodiagnostic tests for the diagnosis of CE is unsatisfactory. Objective: The current study aimed at sub-cloning a gene, encoding the B8/1 subunit ...  Read More

Diospyros peregrina fruit preparation mediated immunomodulation of lymphocytes isolated from the blood of breast cancer patients

Ahana Roy; Aitijhya Ghosh; Kasturi Sinha; Basundhara Mitra; Sudeshna Rakshit; Melvin George; Koustav Sarkar

Volume 18, Issue 2 , June 2021, , Pages 111-118

https://doi.org/10.22034/iji.2021.85430.1710

Abstract
  Background: Breast cancer is an uncontrolled growth of epithelial cells. The loss of BRCA1 activity due to mutation or down-regulation of gene expression promotes tumorigenesis and increases the risk of breast cancer. Objectives: Our aim was to pulsate lymphocytes of breast cancer patients and normal ...  Read More