Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Sclareol Reduces CD4+ CD25+ FoxP3+ T-reg Cells in a Breast Cancer Model in Vivo

Shokoofe Noori; Zuhair Mohammad Hassan; Omid Salehian

Volume 10, Issue 1 , March 2013, , Pages 10-21

Abstract
  Background: Sclareol is a phytochemical used in people's diet in Southeast Asia. Objective: To investigate the immunotherapeutic effectiveness of Sclareol against breast cancer by direct intraperitoneal injection. Methods: Sclareol was isolated and purified from Salvia sclarea. Effect of Sclareol on ...  Read More

Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries

Lida Toomarian; Mandana Sattari; Nazanin Hashemi; Nikoo Tadayon; Alireza Akbarzadeh Baghban

Volume 8, Issue 1 , March 2011, , Pages 11-19

https://doi.org/Immune attributes in S-ECC

Abstract
  Background: The infectious nature of severe early-childhood caries (S-ECC) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products. Objectives: The aim of this study was to determine the neutrophil apoptosis, α-defensins (HNP1-3) ...  Read More

Immunogencity of HSA-L7/L12 (Brucella abortus Ribosomal Protein) in an Animal Model

Iraj Pakzad; Abbas Rezaee; Mohammad Javad Rasaee; Bahman Tabbaraee; Ali Delpisheh

Volume 6, Issue 1 , March 2009, , Pages 12-21

Abstract
  Background: The immunogenic Brucella abortus ribosomal protein L7/L12 is a promising candidate antigen for the development of subunit vaccines against brucellosis. Objective: This study was aimed to evaluate the protection of recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein in Balb/c mice. ...  Read More

The Effect of HLA-DRB1 Sharing between the Couples with Recurrent Pregnancy Loss on the Pregnancy Outcome after Leukocyte Therapy

Behrouz Gharesi-Fard; Rahil Askarinejad-Behbahani; Shabnam Behdin

Volume 11, Issue 1 , March 2014, , Pages 13-20

Abstract
  Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens ...  Read More

TGF-Β1 Transduced Mesenchymal Stem Cells Have Profound Modulatory Effects on DCs and T Cells

Saeed Daneshmandi; Mohammad Hossein Karimi; Ali Akbar Pourfathollah

Volume 14, Issue 1 , March 2017, , Pages 13-23

Abstract
  Background: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. Objectives: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and ...  Read More

Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model

Elham Abdi; Hamid Najafipour; Siyavash Joukar; Shahriar Dabiri; Saeed Esmaeli-Mahani; Elham Abbasloo; Nasrin Houshmandi; Abbas Afsharipour

Volume 15, Issue 1 , March 2018, , Pages 14-27

Abstract
  Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced ...  Read More

TLR agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response

Meiling Hou; Xiaodong Wang; Jike Lu; Xun Guo; Cong Ding; Taotao Liang; Zhenyu Ji; Peng Xie; Xin Liu; Qiaozhen Kang

Volume 17, Issue 1 , March 2020, , Pages 14-25

https://doi.org/10.22034/iji.2020.80291

Abstract
  Background: Melanoma is a common and malignant cutaneous tumor, which is responsible for a large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment of melanoma because of their ability to induce cytotoxic response to facilitate tumor elimination. ...  Read More

Immunophenotypic Subtyping of Leukemic Cells from Iranian Patients with Acute Lymphoblastic Leukaemia: Association to Disease Outcome

Hossein Asgarian Omran; Mahdi Shabani; Tahereh Shahrestani; Abdolfattah Sarafnejad; Jalal Khoshnoodi; Parvaneh Vossough; Mohammad Faranoush; Ramzan A. Sharifian; Mahmood Jeddi-Tehrani; Hodjatallah Rabbani; Fazel Shokri

Volume 4, Issue 1 , March 2007, , Pages 15-25

Abstract
  Background: Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification, stratification and prognosis of leukaemia. Objective: To investigate the immunophenotypic subtype profiles of Iranian patients with acute lymphoblastic leukemia (ALL) and ...  Read More

CD26+ Cord Blood Mononuclear Cells Significantly Produce B, T, and NK Cells

Zeynab Aliyari; Forogh Alemi; Balal Brazvan; Hamid Tayefi Nasrabadi; Hojjatollah Nozad Charoudeh

Volume 12, Issue 1 , March 2015, , Pages 16-26

Abstract
  Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 ...  Read More

Comparison of Functional Competence of Umbilical Cord and Adult Peripheral Blood Dendritic Cells in Allogenic Mixed Leukocyte Reaction

Nahid Naderi; Ali Akbar Pourfathoolah; Mahin Nikougoftar; Kamran Alimoghadam; Ardeshir Ghavamzadeh; Seyed Mohammad Moazzeni

Volume 2, Issue 1 , March 2005, , Pages 21-28

Abstract
  Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity ...  Read More

Immunophenotypic Characterization of the Leukemic B-cells from Iranian Patients with Chronic Lymphocytic Leukemia: Association between CD38 Expression and Disease Progression

Mohammad Hojjat Farasangi; Mahmood Jeddi-Tehrani; Seyed Mohsen Razavi; Ramazan Ali Sharifian; Ahmad Shamsian Khoramabadi; Hojatollah Rabbani; Fazel Shokri

Volume 5, Issue 1 , March 2008, , Pages 25-35

Abstract
  Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. Recent immunophenotypic stud-ies performed mainly in Western populations ...  Read More

Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia

Ali Akbar Amirzargar; Morteza Bagheri; Ardeshir Ghavamzadeh; Kamran Alimoghadam; Farideh Khosravi; Mohammad Hossein Nicknam; Mandana Moheydin; Bita Ansaripour; Batul Moradi; Behrouz Nikbin

Volume 1, Issue 1 , June 2004, , Pages 26-33

Abstract
  Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion ...  Read More

Specific IgE to Common Food Allergens in Children with Atopic Dermatitis

Mozhgan Moghtaderi; Shirin Farjadian; Sara Kashef; Soheila Alyasin; Maryam Afrasiabi; Marzieh Orooj

Volume 9, Issue 1 , March 2012, , Pages 32-38

Abstract
  Background: Atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. Although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about ...  Read More

Determination of Soluble HER-2/neu (sHER-2/neu) in Iranian Patients with Lung Cancer

Seyyed Mohammad Ali Ghayumi; Kambiz Aghasadeghi; Mehrnoosh Dorouchi; Abbas Ghaderi

Volume 3, Issue 2 , June 2006, , Pages 61-65

Abstract
  Background: The HER-2/neu gene is located on chromosome 17q21 and encodes a 185-kDa transmembrane glycoprotein with tyrosine kinase activity reported to be released in soluble form in various malignancies. Objective: To evaluate the clinical significance of soluble Her-2/neu as a diagnostic marker in ...  Read More

The Effects of Candida Albicans Cell Wall Protein Fraction on Dendritic Cell Maturation

Maryam Roudbary; Shahla Roudbar Mohammadi; Mahmood Bozorgmehr; Seyed Mohammad Moazzeni

Volume 6, Issue 2 , June 2009, , Pages 67-74

Abstract
  Back ground: Candida albicans is a member of the normal human microflora. C. albicans cell wall is composed of several protein and carbohydrate components which have been shown to play a crucial role in C. albicans interaction with the host immune system. Major components of C. albican cell wall are ...  Read More

Long Acting Propranolol and HSP-70 Rich Tumor Lysate Reduce Tumor Growth and Enhance Immune Response against Fibrosarcoma in Balb/c Mice

Ahmad Khalili; Zuhair Muhammad Hassan; Shahram Shahabi; Ali Akbar Pourfathollah; Seyed Nasser Ostad; Shokoofe Noori; Mehdi Mahdavi; Habib Haybar; Ladan Langroudi

Volume 10, Issue 2 , June 2013, , Pages 70-82

Abstract
  Background: Noradrenaline (NA), the principal neurotransmitter released from sympathetic nerve terminals, influences T-cell maturation, not only directly in developing T cells, but also indirectly, by acting on the thymic nonlymphoid cells. In vitro and in vivo studies have demonstrated the anti-proliferative, ...  Read More

Toll Like Receptor 2 and 4 Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients

Seyed Javad Hasheminia; Sayyed Hamid Zarkesh-Esfahani; Sepideh Tolouei; Vahid Shaygannejad; Hedaiatallah Shirzad; Morteza Hashemzadeh Chaleshtory

Volume 11, Issue 2 , June 2014, , Pages 74-83

Abstract
  Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. Ligation of TLR-2 and TLR-4 stimulates the production of several cytokines leading ...  Read More

In Vivo Effects of Calcitriol on Phenotypic and Functional Properties of Dendritic Cells

Mohammad Mahdi Eftekharian; Amir Hassan Zamani; Seyed-Mohammad Moazzeni

Volume 7, Issue 2 , June 2010, , Pages 74-82

Abstract
  Background: Dendritic cells (DCs) play a central role in the initiation and expansion of T cell mediated immune responses with potential immunotherapy application. The compounds which have the ability to induce immunomodulatory effects on DCs may be employed for the treatment of immunopathologic conditions ...  Read More

Effect of LIGHT Adjuvant on Kinetics of T-Cell Responses Induced by HSV-1 DNA Immunization

Masumeh Gorgian Mahmoody; Taravat Bamdad; Maoud Pasania; Hoorieh Soleimanjahi; Somayeh Pouyanfard; Hamidreza Hashemi; Mohammad Asghari-Jafarabadi

Volume 8, Issue 2 , June 2011, , Pages 76-84

Abstract
  Background: Studies on efficacy of various vaccines that prevent or reduce the primary and recurrent HSV-1 infection have demonstrated the importance of cellular immunity for protection against the infection. We previously used DNA vaccination to induce cellular immunity against HSV-1 infection in mice. ...  Read More

Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

Mahmoud Orazizadeh; Donald M Salter

Volume 2, Issue 2 , June 2005, , Pages 78-86

Abstract
  Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) ...  Read More

Positional Relationship between Natural Killer Cells and Distribution of Sympathetic Nerves in Decidualized Mouse Uterus

Abdolkarim Sheikhi; Hossein B. Ganji; Razieh Sheikhi

Volume 4, Issue 2 , June 2007, , Pages 79-84

Abstract
  Background: Uterine natural killer (uNK) cells are the most abundant leukocytes in pre-implantation endometrium and early pregnancy deciduas in humans and rodents. They are associated with structural changes in maternal spiral arteries but regulation of their re-cruitment and activation is incompletely ...  Read More

CTL Responses to a DNA Vaccine Encod-ing E7 Gene of Human Papillomavirus Type 16 from an Iranian Isolate

Zahra Meshkat; Hoorieh Soleimajjahi; Mahmoud Mahmoudi; Zuhair Mohammad Hassan; Hessam Mirshahabi; Mojtaba Meshkat; Maryam Kheirandish

Volume 5, Issue 2 , June 2008, , Pages 82-91

https://doi.org/10.22034/iji.2008.17104

Abstract
  Background: Cervical cancer is the most prevalent tumor in developing countries and the second most frequent cancer among female population worldwide. Specific human papillomaviruses and, most notably, HPV types 16 and 18 are recognized as being caus-ally associated with cervical carcinomas. The early ...  Read More

Immune Responses against a New HIV-1 p24-gp41/pCAGGS-IL-12 DNA Vaccine in Balb/c Mice

Fatemeh Roodbari; Farzaneh Sabahi; Mohamad Nabi Sarbolouki; Farzaneh Barkhordari; Ahmad Adeli; Amel Jamedar; Fereidoun Mahboudi

Volume 9, Issue 2 , June 2012, , Pages 86-97

Abstract
  Background: Development of an effective vaccine is highly needed in order to restrict the AIDS pandemic. DNA vaccines initiate both arms of immunity without the potential of causing disease. HIV-1 p24 and gp41 (gag and env) proteins play important roles in viral pathogenesis and are effective candidates ...  Read More

B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation

Yongan Liu; Wei Nie; Yu Jin; Anshan Zhuo; Yuansheng Zang; Qingyu Xiu

Volume 13, Issue 2 , June 2016, , Pages 89-99

Abstract
  Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: ...  Read More