Reza Farid Hosseini; Farahzad Jabbari Azad; Ali Talaee; Sara Miri; Naghme Mokhber; Farhad Farid Hosseini; Habibollah Esmaeili; Mahmoud Mahmoudi; Hoshang Rafatpanah; Mohammadreza Mohammadi
Volume 4, Issue 1 , March 2007, , Pages 38-43
Abstract
Background: Major Depression Disorder (MDD) is a common disorder with preva-lence of 15% among men and up to 25% among women. In recent years the association of immune system alterations and MDD has been investigated. Assessments of immu-nologic and inflammatory responses in these patients enhance our ...
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Background: Major Depression Disorder (MDD) is a common disorder with preva-lence of 15% among men and up to 25% among women. In recent years the association of immune system alterations and MDD has been investigated. Assessments of immu-nologic and inflammatory responses in these patients enhance our knowledge of the eti-ology and pathogenesis of this disease. Objective: To investigate the changes in immu-noglobulin and cytokine serum levels and lymphocyte subsets in patients with MDD. Methods: We studied 37 adult patients with MDD, diagnosed based on DSM-IV diag-nostic criteria, and 15 healthy controls matched with the patients. Plasma concentration of interleukin-4 (IL-4), IL-10, TNF α, and IFN γ were measured by ELISA and serum immunoglobulins by SRID. Total number of NK cells (CD16 and CD56), B cells (CD19), and T cells (CD8, CD4, and CD3) were determined by flow cytometry. Results: We found no significant differences in plasma concentration of IL-4, IL-10, TNF-α, IFN-γ, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. Conclusion: We conclude that in our patients, there were no significant differences in immune system ac-tivity between MDD patients and controls.
Reza Farid; Farahzad Jabbari Azad; Javad Gaffari; Alireza Rangbar; Zahra Nikjoy
Volume 1, Issue 1 , June 2004, , Pages 71-75
Abstract
Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response ...
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Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glutathione peroxides and changes in its plasma level has been proposed to be associated with allergic diseases. Materials and Methods: This study comprised of 21 cases of allergic asthma (AA), 33 cases of allergic rhinitis (AR) whose age and sex were matched with 28 healthy controls. IL-4, IL-10, IFN-g levels were tested by ELISA assay, and serum selenium was measured by atomic absorption spectorphotometery method. Results: Mean serum selenium level of AA and AR groups were lower than controls. Mean serum IL-4 level of AA was higher than the AR group. Mean serum IL-4 level of AA and AR group were higher than controls. Conclusion: The results of this study indicate that low selenium level may have a role in the pathogenesis of allergic diseases.