Ali Ghasemi; Hoorieh Soleimanjahi; Soodeh Razeghi; Ali Gorji; Alijan Tabaraei; Abdolvahab Moradi; Akram Alizadeh; Mohammad Ali Vakili
Volume 9, Issue 2 , June 2012, , Pages 119-127
Abstract
Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 tumor cell line were evaluated in adult female ...
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Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 tumor cell line were evaluated in adult female C57BL/6 mice. Methods: Mice were treated with GEN 10 days before to 10 days after the tumor induction. Thirty days after the last GEN treatment, lymphocyte proliferation, Lactase Dehydrogenase (LDH) cytolytic activity and cytokine secretion were analyzed in GEN and control groups. Results: The results showed that ingestion of genistein significantly increased lymphocyte proliferation and LDH release. Furthermore, the treatment with genistein also caused a significant increment in interferon gamma (IFN-γ). In addition, the treatment achieved significant therapeutic effect in tumor models compared to the control group. These results indicated that the effect of GEN on tumor growth may be attributed to its effect on lymphocyte proliferation, cytolytic activity and IFN-γ production. Conclusion: These results demonstrate that GEN exerts an immunomodulatory effect in a mouse model of Human Papillomavirus (HPV) associated-cervical cancer.
Maryam Kasraeian; Marjan Movaseghii; Alireza Fotouhi Ghiam
Volume 1, Issue 3 , December 2004, , Pages 189-193
Abstract
Background: Herpes Simplex Virus (HSV) Type 2 is a widespread human infectious agent responsible for persistent and latent infections. Objectives: To estimate the regional seroprevalence of anti HSV-2 antibody in Shiraz, Iran and to investigate the possible correlation of seropositivity with malignant ...
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Background: Herpes Simplex Virus (HSV) Type 2 is a widespread human infectious agent responsible for persistent and latent infections. Objectives: To estimate the regional seroprevalence of anti HSV-2 antibody in Shiraz, Iran and to investigate the possible correlation of seropositivity with malignant changes in subjects’ Papanicolaou (Pap) tests. Methods: Data were collected in a cross-sectional study. A randomly selected population of 915 women, from nine primary health care centers according to regional population size, was recruited in this study. HSV type specific serum IgG was determined by an Enzyme Linked Immunosorbent assay. Results: The overall seroprevalence of HSV-2 antibody was 258/915 (28.19%). Most of the seropositive cases (87.6%) were categorized in the group of less educated women. None of the individuals with positive serum antibody had malignant change in the uterine cells obtained with the help of Pap smear. Conclusion: HSV-2 infection is relatively common and largely unrecognized among our study participants. The HSV-2 antibody was more prevalent in the studied population in comparison with European and American women, and less prevalent than African women. Although HSV-2 is reported to be in correlation with cervical cancer, none of our studied subjects had any malignant change in cervical cells.
