Mina Biria; Mandana Sattari; Mojtaba Vahid Golpayegani; Fahimeh Kooshki
Volume 7, Issue 3 , September 2010, , Pages 193-197
Abstract
Background: Early childhood caries (ECC) is a severe type of dental caries affecting infants and pre-school children. Because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development. Objective: This study investigated the association between ...
Read More
Background: Early childhood caries (ECC) is a severe type of dental caries affecting infants and pre-school children. Because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development. Objective: This study investigated the association between the presence of salivary sCD14 and ECC. Methods: This study was carried out on 40 healthy children, of whom 20 were caries-free (CF) and 20 had ECC, within the ages of 36 to 71 months. Unstimulated saliva of the children was collected with disposable needle-less syringe from buccal and labial vestibules. Seven children with ECC received complete treatments. Saliva was collected for a second time after 3 months from this group. The sCD14 levels in salivary samples were analyzed by ELISA method. Results: Mean concentrations of sCD14 in ECC and CF groups were 57.82 and 31.92 ng/ml respectively (p=0.008). After three months, the mean concentration of sCD14 among the treated children decreased to 11.38 ng/ml, which was significantly lower compared to that of ECC children before intervention (p<0.001), and also CF children (p<0.05). Conclusion: The increased levels of sCD14 can be considered as a marker of inflammation and innate immune response during ECC.
Ali Bagherian; Abdullah Jafarzadeh; Mohsen Rezaeian; Shima Ahmadi; Mohammad Taghi Rezaity
Volume 5, Issue 4 , December 2008, , Pages 217-221
Abstract
Background: Early Childhood Caries (ECC) is one of the most common chronic child-hood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few indus-trialized nations. Saliva as a host factor can ...
Read More
Background: Early Childhood Caries (ECC) is one of the most common chronic child-hood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few indus-trialized nations. Saliva as a host factor can play an important role in the process of den-tal caries. Objective: The aim of this study was to compare sIgA and IgG as saliva components between ECC and caries-free groups. Methods: In this cross-sectional study, samples of unstimulated saliva of 90 children (45 in ECC group & 45 in caries-free group) were taken with Scully method. Then the concentration levels of sIgA and IgG were measured with Enzyme Linked Immunosorbent Assay and Single Radial Im-munodiffusion methods. Results: Mean concentration levels of salivary sIgA and IgG were significantly higher among children with ECC (p<0.05). There was also a weak inverse correlation between sIgA level and DMFT index in ECC group but it was not statistically significant (p=0.056). Conclusion: The high concentration of salivary im-munoglobulin in children with ECC may be associated with an increased antigenic load, leading to high production of antibodies.
