Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis

Guoqing Gong; Peng Huang; Changliang Yang; Chengcheng Huang; Zhao Zhang; Ruiyao Chen; Tingfeng Sun; Guang Yang

Volume 20, Issue 3 , September 2023, , Pages 287-302

https://doi.org/10.22034/iji.2023.96966.2473

Abstract
  Background: Type 2 innate lymphoid cells (ILC2s) and NLRP3 inflammasome are related to allergic and inflammatory responses. NLRP3 inflammasome inhibitor MCC950 was demonstrated to ameliorate allergic rhinitis (AR) in animal models.Objective: To elucidate the effect of MCC950 on ILC2 responses in AR.Methods: ...  Read More

Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response

Dan Luo; Jun Li; Manli Hu; You Wang; Pei Pi; Min Ning; Jun Wu

Volume 20, Issue 3 , September 2023, , Pages 316-326

https://doi.org/10.22034/iji.2023.97942.2541

Abstract
  Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN.Objective: To investigate the detailed role and ...  Read More

Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells

Yan Tan; Si-Wei Tan; Bo-Ya Fan; Lei Li; Yuan-Guo Zhou

Volume 15, Issue 2 , June 2018, , Pages 122-132

https://doi.org/10.22034/iji.2018.39376

Abstract
  Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship ...  Read More