@article { author = {Orazizadeh, Mahmoud and Salter, Donald M}, title = {Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage}, journal = {Iranian Journal of Immunology}, volume = {2}, number = {2}, pages = {78-86}, year = {2005}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.   Methods: Using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of Galectin-3 in normal and OA human articular cartilage were assessed.   Results: Immunohistochemical studies showed a similar pattern of Galectin-3 expression in normal and mild OA but severe OA showed different strong expression in all zones of human articular cartilage.   Conclusion: Increased expression pattern of Galectin-3 in advanced stages of OA may occur as a result of the imbalance of chondrocyte homeostasis that occurs in OA cartilage and provides a condition to modify normal chondrocyte to an OA chondroctye.}, keywords = {Articular Cartilage,Galectin-3,Osteoarthritis}, url = {https://iji.sums.ac.ir/article_16844.html}, eprint = {https://iji.sums.ac.ir/article_16844_a124cc9fab8cc57f5811a5034d80d8fd.pdf} }