@article { author = {Mishra, Mahendra Narin and Bharucha, Khurshed Minoo}, title = {HLA-B27 Association with Uveitis in an Asian Indian Population}, journal = {Iranian Journal of Immunology}, volume = {8}, number = {2}, pages = {85-89}, year = {2011}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. Objectives: To establish the frequency of HLA-B27- positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature. Methods: We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required. Results: The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance. Conclusions: HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment.}, keywords = {Asian,HLA-B27,Indian,Uveitis}, url = {https://iji.sums.ac.ir/article_16892.html}, eprint = {https://iji.sums.ac.ir/article_16892_402f5d2aabd8b7454477f8159398f64d.pdf} }