@article { author = {Ghayumi, Seyyed Mohammad Ali and Aghasadeghi, Kambiz and Dorouchi, Mehrnoosh and Ghaderi, Abbas}, title = {Determination of Soluble HER-2/neu (sHER-2/neu) in Iranian Patients with Lung Cancer}, journal = {Iranian Journal of Immunology}, volume = {3}, number = {2}, pages = {61-65}, year = {2006}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: The HER-2/neu gene is located on chromosome 17q21 and encodes a 185-kDa transmembrane glycoprotein with tyrosine kinase activity reported to be released in soluble form in various malignancies. Objective: To evaluate the clinical significance of soluble Her-2/neu as a diagnostic marker in lung cancer. Methods: Serum levels of soluble HER-2/neu were measured in 43 patients with lung cancer and 42 age and sex matched controls by an enzyme immunoassay method. Results: Mean serum level of soluble Her-2/neu in cancer patients was 6.07±10.37 ng/ml which was significantly higher than the control group (P < 0.05). Cigarette smoking had no effect on the level of soluble HER-2/neu. A cut off value of 6.1ng/ml revealed a high specificity (95%) for diagnosis of lung cancer, but a very low sensitivity (14%). Conclusion: The results of this study show an increased level of soluble HER-2/neu in the sera of lung cancer patients with a high specificity but low sensitivity for diagnosis of lung cancers.}, keywords = {Lung Cancer,HER2/neu,Iran}, url = {https://iji.sums.ac.ir/article_16960.html}, eprint = {https://iji.sums.ac.ir/article_16960_6b1cfccfbda77efb374c1aff69b03d4b.pdf} }