@article { author = {Shahsavar, Farhad and Tajik, Nader and Entezami, Kobra-Zinat and Fallah Radjabzadeh, Masoomeh and Asadifar, Behnam and Alimoghaddam, Kamran and Ostadali Dahaghi, Mohammadreza and Jalali, Arash and Ghashghaie, Andisheh and Ghavamzadeh, Ardeshir}, title = {KIR2DS3 is Associated with Protection against Acute Myeloid Leukemia}, journal = {Iranian Journal of Immunology}, volume = {7}, number = {1}, pages = {8-17}, year = {2010}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML; n=40) and acute lymphoid leukemia (ALL; n=38) were genotyped for seventeen KIR genes and their three major HLA class I ligand groups (C1, C2, Bw4) by a combined polymerase chain reaction–sequence-specific primers (PCR-SSP) assay. The results were compared with those of 200 healthy control individuals. Results: We found a significantly decreased frequency of KIR2DS3 in AML patients compared to control group (12.5% vs. 38%, odds ratio=0.23, p=0.0018). Also, the KIR3DS1 was less common in AML group than controls (27.5% vs. 44.5%, p=0.0465, not significant after correction). Other analyses including KIR genotypes, distribution and balance of inhibitory and activating KIR+HLA combinations, and co-inheritance of activating KIR genes with inhibitory KIR+HLA pairs were not significantly different between leukemia patients and the control group. However, in AML patients a trend toward less activating and more inhibitory KIR-HLA state was observed. Interestingly, this situation was not found in ALL patients and inhibition enhancement through increase of HLA ligands and inhibi-tory combinations was the main feature in this group. Conclusion: Our findings may suggest a mechanism for escape of leukemic cells from NK cell immunity.}, keywords = {Acute Leukemia,Genotype,HLA,KIR}, url = {https://iji.sums.ac.ir/article_17035.html}, eprint = {https://iji.sums.ac.ir/article_17035_2ae84eeb0b534347ce5d1ef9f5be0168.pdf} }