@article { author = {Babaloo, Zohreh and Babaie, Farhad and Farhoodi, Mehdi and Aliparasti, Mohammadreza and Baradaran, Behzad and Almasi, Shohreh and Hosseini, Ahmad}, title = {Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis}, journal = {Iranian Journal of Immunology}, volume = {7}, number = {4}, pages = {1-1}, year = {2010}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17- producing T cells which are consider as dominant effectors for inducing autoimmune tissue inflammation. Objective: The objective of this study was to assess the role of IL-17A and IL-17F in MS pathogenesis. Methods: We evaluated mRNA expression of IL-17A and IL-17F in thirty-five Iranian patients with relapsing–remitting MS (RRMS) and twenty-five healthy controls by Quantitative Real Time PCR. Results: The results of this study showed a twenty-fold increase in the expression of IL-17A mRNA in MS patients compared to the control group (p < 0.0001 ). IL-17F mRNA expression in MS patients was thirty three-times greater than control group (p = 0.0008). IL-17A mRNA expression in periphery was positively correlated with expression of IL-17F transcripts in MS patients and controls (p < 0.01 and p < 0.05, respectively). Conclusion: These results indicate the critical role of Th17- mediated cytokines in development of MS which classically has been considered as a Th1-mediated disorder. The results of this study showed, for the first time, the importance of IL-17F in MS immunopathogenesis.}, keywords = {Multiple Sclerosis (MS),IL-17A,IL-17F,mRNA gene expression}, url = {https://iji.sums.ac.ir/article_17059.html}, eprint = {https://iji.sums.ac.ir/article_17059_d081da0cc60e1c85f0d5774bd8186a7c.pdf} }