@article { author = {Jahadi Hosseini, Hamid Reza and Kamali Sarvestani, Eskanadar and Akbari, Mitra and Mosallaei, Mahnaz}, title = {Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection}, journal = {Iranian Journal of Immunology}, volume = {6}, number = {1}, pages = {28-32}, year = {2009}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. Methods: In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction (ASO-PCR) techniques. Results: There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode (p=0.35). Moreover, the relationship between this polymorphism and rejection episode outcome (transplant recovery vs failure) was not statistically significant (p=0.13). Conclusion: The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism.}, keywords = {Corneal Transplantation,Fas Ligand,Rejection}, url = {https://iji.sums.ac.ir/article_17070.html}, eprint = {https://iji.sums.ac.ir/article_17070_f2fbe5d24151c6534cb3dd5916b87a3d.pdf} }