%0 Journal Article %T Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris %J Iranian Journal of Immunology %I Shiraz Institute for Cancer Research %Z 1735-1383 %A Pouralibaba, Firouz %A Babaloo, Zohreh %A Pakdel, Farzaneh %A Abdollahian, Tahmoores %A Pourzare, Solmaz %D 2012 %\ 12/01/2012 %V 9 %N 4 %P 261-265 %! Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris %K autoimmune disease %K Interleukin-23 %K Pemphigus Vulgaris %R %X Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and exclusion criteria. Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data was analyzed using Student’s t-test for comparison of IL-23 levels between the two groups. Results: Mean serum levels of IL-23 in patients with pemphigus and healthy controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p<0.05). Conclusions: Based on the findings of this study, serum levels of IL-23 were higher in patients with pemphigus in comparison to healthy individuals with no clinical significance. %U https://iji.sums.ac.ir/article_16880_1515cf78ed76da64b0336c1d188d606f.pdf