TY - JOUR ID - 16710 TI - Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Farid, Reza AU - Jabbari Azad, Farahzad AU - Gaffari, Javad AU - Rangbar, Alireza AU - Nikjoy, Zahra AD - Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Koeln Immunology Research Center, Germany Y1 - 2004 PY - 2004 VL - 1 IS - 1 SP - 71 EP - 75 KW - Allergic Rhinitis KW - Eosinophilia KW - prevalence DO - N2 - Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glutathione peroxides and changes in its plasma level has been proposed to be associated with allergic diseases. Materials and Methods: This study comprised of 21 cases of allergic asthma (AA), 33 cases of allergic rhinitis (AR) whose age and sex were matched with 28 healthy controls. IL-4, IL-10, IFN-g levels were tested by ELISA assay, and serum selenium was measured by atomic absorption spectorphotometery method. Results: Mean serum selenium level of AA and AR groups were lower than controls. Mean serum IL-4 level of AA was higher than the AR group. Mean serum IL-4 level of AA and AR group were higher than controls. Conclusion: The results of this study indicate that low selenium level may have a role in the pathogenesis of allergic diseases. UR - https://iji.sums.ac.ir/article_16710.html L1 - https://iji.sums.ac.ir/article_16710_275232b3681d3bfa4e90926bdb60acbb.pdf ER -