TY - JOUR ID - 16726 TI - Effect of Anger Patterns and Depression on Serum IgA and NK Cell Frequency JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Farnam, Alireza AU - Majidi, Jafar AU - Nourazar, Seyyed Gholamreza AU - Ghojazadeh, Morteza AU - Movassaghpour, Aliakbar AU - Majidi Zolbanin, Saeedeh AD - Psychiatry and Behavioral Sciences Research Center AD - Department of Immunology, Faculty of Medicine AD - Liver and Gastrointestinal Disease Research Center AD - Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Y1 - 2016 PY - 2016 VL - 13 IS - 1 SP - 37 EP - 44 KW - Anger KW - depression KW - Immunoglobulin A KW - Natural Killer Cell DO - N2 - Background: There are conflicting findings about relationship between depression and anger with immunological parameters. Objective: To investigate the relationship between anger patterns and immune system in depressed patients. Methods: Thirty-five patients with major depressive disorder were selected according to DSM-IV criteria. The Hamilton Depression Scale and Spielberger Anger questionnaires were used to determine severity of depression and "anger expression pattern", respectively. The control group without a previous history of mental illness was also selected. In the group of patients with moderate depression, serum IgA levels and NK cell percentage were measured. Results: Mean differences of all types of "anger expression pattern", including; "state-trait anger", "anger expression out", "anger expression in", "anger control out" and "anger control in", between study and control groups, were statistically significant (p<0.05). Difference in mean serum levels of IgA in either group was not significant (p=0.9), but the mean difference was significant in terms of NK-cell percentage in both groups (p=0.04). There was no significant relationship between IgA levels and percentage of NK-cell with all types of "anger expression pattern" in both groups. Only in the control group, IgA had significant correlation with Anger control out (p=0.04). Conclusion: Moderately depressed patients versus control group had higher Spielberger scores in all types of anger expression pattern except anger controlout and anger control-in. We found no evidence supporting the relationship between" anger expression pattern" and IgA levels and NK cell percentage; however, it seems that depression itself causes reduced number of NK cells and increased IgA levels. UR - https://iji.sums.ac.ir/article_16726.html L1 - https://iji.sums.ac.ir/article_16726_6cbb8c20c419a5427a14aecb7f9cb263.pdf ER -