TY - JOUR ID - 16770 TI - IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Bahadori, Motahareh AU - Zarei, Saeed AU - Zarnani, Amir Hassan AU - Zarei, Omid AU - Idali, Farah AU - Hadavi, Reza AU - Jeddi-Tehrani, Mahmood AD - Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran AD - Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz AD - Nano biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran AD - Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz AD - Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Y1 - 2014 PY - 2014 VL - 11 IS - 2 SP - 97 EP - 104 KW - Cytokine KW - Gene Polymorphism KW - PCR-RFLP KW - Recurrent Miscarriage DO - N2 - Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) was performed to determine the frequencies of the IL-6, IL-10 and IL-17 gene polymorphisms in 85 women with RM compared with 104 healthy controls. Results: The frequencies of IL- 10 promoter gene polymorphisms (-592 A/C and -819 C/T) were significantly higher in RM women than those in controls (p=0.003). However, no statistically significant differences were observed in the frequencies of IL-6 (-174 C/G), IL-10 (-1082 A/G) and IL-17 (-197 G/A) polymorphisms between RM women and controls. Conclusion: These results suggest that IL-10 gene polymorphism screening might have some relevance in patients with RM, a suggestion which requires further studies. UR - https://iji.sums.ac.ir/article_16770.html L1 - https://iji.sums.ac.ir/article_16770_f3496520f99b1a38f509ff21368eb629.pdf ER -