TY - JOUR ID - 16791 TI - Differential Immunogenicity of A Recombinant Hepatitis B Vaccine in Iranian Neonates: Influence of Ethnicity and Environmental Factors JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Jafarzadeh, Abdollah AU - Khoshnoodi, Jalal AU - Ghorbani, Shayesteh AU - Mohaghegh Hazrati, Saleh AU - Faraj Mazaheri, Babak AU - Shokri, Fazel AD - Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran AD - Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran AD - Kerman Health Center, Kerman University of Medical Sciences, Kerman AD - Health Research Center of Urmia, Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2004 PY - 2004 VL - 1 IS - 2 SP - 98 EP - 104 KW - Ant i-HBs antibody KW - Hepatitis B KW - Vaccinat ion KW - Immunogenicit y KW - neonate KW - Seroprotection DO - N2 - Objective: To compare immunogenicity of a recombinant hepatitis B (HB) vaccine in two groups of neonates born in two cities of Iran with different geographic and ethnic backgrounds.   Materials and Methods: Ten micrograms of a recombinant HB vaccine was administered under field condition to Iranian healthy neonates at 0, 1.5 and 9 months intervals. The subjects consisted of two groups of 290 and 231 neonates selected from two cities located at north-west (Urmia) and south-east (Kerman) of Iran, respectively. The level of anti-HBs antibody was quantitated in serum 2-4 weeks after administration of the last vaccine dose, by sandwich ELISA.   Results: A higher seroprotection rate (anti-HBs> 10 IU/L) (98.3% vs. 96.1%) and significantly increased serum anti- HBs antibody titer (11869 vs. 6104 IU/L) (P<0.001) were induced in vaccinated neonates from Urmia city, compared to those born in Kerman.   Conclusion: These findings suggest contribution of ethnic and/or environmental factors in the antibody response to recombinant HB vaccine in human. UR - https://iji.sums.ac.ir/article_16791.html L1 - https://iji.sums.ac.ir/article_16791_a99e7cc36fd489f9b755193bf24f631c.pdf ER -