TY - JOUR ID - 16796 TI - Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Rafinejad, Ali AU - Niknam, Mohammad Hossein AU - Amirzargar, Ali Akbar AU - Khosravi, Farideh AU - Karimi, Forouzan AU - Larijani, Bagher AD - Department of Immunology, School of Medicine, Tehran University of Medical Sciences AD - Iranian National Research Center for Medical Sciences of I.R. IRAN AD - Endocrinology and Metabolism Research Center, Tehran, Iran. Y1 - 2004 PY - 2004 VL - 1 IS - 2 SP - 130 EP - 132 KW - Cytokine KW - Polymorphism KW - Type 1 Diabetes Mellitus DO - N2 - Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.   Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.   Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN-   ¹ gene was evaluated at position 5’UTR +5644. Results: There was a significant difference between patient and control groups in TT genotype (P<0.05). Conclusion: In this study, we found a negative association between IFN-¹ gene at position 5’UTR +5644 and T1D in Iranian patients pointing to T allele as a protective factor against T1D. UR - https://iji.sums.ac.ir/article_16796.html L1 - https://iji.sums.ac.ir/article_16796_8f7ba0beed815ec9466737a4202bffbc.pdf ER -