TY - JOUR ID - 16824 TI - KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Ashouri, Elham AU - Dabbaghmanesh, Mohammad Hossein AU - Hadaegh, Amirhossein AU - Rowhanirad, Soodeh AU - Bakhshayeshkaram, Marizeh AU - Ranjbar Omrani, Gholamhossein AD - Endocrinology and Metabolism Research Center AD - Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2013 PY - 2013 VL - 10 IS - 3 SP - 150 EP - 157 KW - Graves’ Disease KW - KIR Gene KW - PCR-SSP DO - N2 - Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy. Methods: KIR genes profiles were analyzed in 90 patients presenting Graves’ disease with ophthalmopathy representing upper eyelid retraction, swelling, redness, conjunctivitis, and bulging eyes and were compared with the KIR gene profiles of 112 healthy controls. The presence and absence of 11 variable KIR genes were characterized using a gene-specific PCR typing system. Results: There was no significant difference in the distribution of KIR gene profiles between patients and controls. Conclusion: Our data show that none of the KIR genotypes contribute in susceptibility to Graves’ disease; although the role of HLA ligand remains to be characterized. UR - https://iji.sums.ac.ir/article_16824.html L1 - https://iji.sums.ac.ir/article_16824_c88b62c069d4b5f94aa2cf3e3c98d5a9.pdf ER -