TY - JOUR ID - 16844 TI - Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Orazizadeh, Mahmoud AU - Salter, Donald M AD - Department of Histology, Medical School, Ahwaz Jondishapour University of Medical Sciences (AJUMS), Ahwaz, Iran AD - Department of Pathology, Medical School, Edinburgh University, Edinburgh, Scotland, UK Y1 - 2005 PY - 2005 VL - 2 IS - 2 SP - 78 EP - 86 KW - Articular Cartilage KW - Galectin-3 KW - Osteoarthritis DO - N2 - Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.   Methods: Using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of Galectin-3 in normal and OA human articular cartilage were assessed.   Results: Immunohistochemical studies showed a similar pattern of Galectin-3 expression in normal and mild OA but severe OA showed different strong expression in all zones of human articular cartilage.   Conclusion: Increased expression pattern of Galectin-3 in advanced stages of OA may occur as a result of the imbalance of chondrocyte homeostasis that occurs in OA cartilage and provides a condition to modify normal chondrocyte to an OA chondroctye. UR - https://iji.sums.ac.ir/article_16844.html L1 - https://iji.sums.ac.ir/article_16844_a124cc9fab8cc57f5811a5034d80d8fd.pdf ER -