TY - JOUR ID - 16879 TI - Association of Haptoglobin Phenotypes with Serum Levels of IgE and IgA in Allergic Rhinitis Patients JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Khazaei, Hossein Ali AU - Nakhaei, Alireza AU - Dashti, Golam Ali AU - Mohammadi, Mehdi AU - Hejazenia, Fariba AU - Mehrangeez, Noura AU - Khazaei, Amin AD - Department of Immunology and Hematology, Cellular and Molecular Research Center AD - Department of Biochemistry AD - Department of ENT AD - Department of Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Y1 - 2012 PY - 2012 VL - 9 IS - 4 SP - 254 EP - 260 KW - Allergic Rhinitis KW - Haptoglobin KW - IgA KW - IgE DO - N2 - Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels in patients suffering from AR in comparison with healthy individuals. Methods: Two hundred and forty patients and 240 healthy individual entered in this case-control study. Serum levels of IgE and IgA were measured and haptoglobulin phenotypes were determined by electrophoresis. The results were evaluated by χ2 statistical test using SPSS software. Results: Serum electrophoresis showed that the distribution of haptoglobin phenotypes of Hp1-1, Hp2-1 and Hp2-2 among 240 patients were 11.3%, 37.9% and 50.8%, respectively. The distribution of different haptoglobin phenotypes in healthy controls were 88.7%, 36.6% and 54.7%, respectively. However, the difference between patients and controls was not statistically significant (p=0.136). The mean of IgE level was significantly higher in patients than controls in association with all three phenotypes (p<0.001). Mean of IgA serum level was also significantly different between case and control groups for Hp1-1 (p<0.048) and Hp2-2 phenotypes (p<0.027). Conclusion: We conclude that there is an association of all three haptoglobin phenotypes with IgE level. Hp1-1 and Hp2-2 phenotypes showed association with IgA in allergic rhinitis, as well. However, we cannot solely attribute these associations to the pathogenesis of allergic rhinitis. UR - https://iji.sums.ac.ir/article_16879.html L1 - https://iji.sums.ac.ir/article_16879_f0421496eb677568a77afab2872a4cc2.pdf ER -