TY - JOUR ID - 16892 TI - HLA-B27 Association with Uveitis in an Asian Indian Population JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Mishra, Mahendra Narin AU - Bharucha, Khurshed Minoo AD - Dr. Lal Pathology Reference Laboratory, New Delhi AD - Department of Ophthalmology, Command Hospital (SC), Pune, India Y1 - 2011 PY - 2011 VL - 8 IS - 2 SP - 85 EP - 89 KW - Asian KW - HLA-B27 KW - Indian KW - Uveitis DO - N2 - Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. Objectives: To establish the frequency of HLA-B27- positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature. Methods: We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required. Results: The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance. Conclusions: HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment. UR - https://iji.sums.ac.ir/article_16892.html L1 - https://iji.sums.ac.ir/article_16892_402f5d2aabd8b7454477f8159398f64d.pdf ER -