TY - JOUR ID - 17026 TI - Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Ghayumi, Mohammad Ali AU - Mojtahedi, Zahra AU - Fattahi, Mohammad Javad AD - Institute for Cancer Research AD - Institute for Cancer Research Y1 - 2011 PY - 2011 VL - 8 IS - 4 SP - 195 EP - 200 KW - IFN-γ KW - IL-4 KW - Lung Cancer KW - Pleural Effusion DO - N2 - Background: The alteration of Th1 and Th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a Th2 immune response. Objective: To examine the different levels of IL-4 and IL-10 (Th2 cytokines), and IL-2 and interferon-γ (IFN-γ) (Th1 cytokines) in malignant and non-malignant pleural effusions. Method: The cytokine levels in pleural fluid of 62 patients with malignant pleural effusion (44 with lung cancer and 18 with extrathoracic tumors), 8 with tuberculous and 8 with congestive heart failure pleural effusion were analysed using enzymelinked immunosorbent assays. Results: IL-2 was below the detectable concentration of the assay. A significant decrease in IFN-γ level was observed in malignant but not in congestive heart failure cases compared to tuberculous cases. IL-10 levels were higher in malignant and tuberculous pleural effusions than in congestive heart failure pleural effusions, however, this difference did not reach the significant level. IL-4 levels were also increased non-significantly in lung cancer pleural effusions compared to the other groups. Conclusion: Our results show a wide variation in IL-4, IL-10, and IFN-γ levels in malignant pleural effusions, a pattern which was not convincing enough to differentiate the cause of effusion. UR - https://iji.sums.ac.ir/article_17026.html L1 - https://iji.sums.ac.ir/article_17026_139f99792449cf587d5584b1137c7af2.pdf ER -