TY - JOUR ID - 17065 TI - Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - AMirshahrokhi, Keyvan AU - Ghazi-khansari, Mahmoud AU - Mohammadi-Farani, Ahmad AU - Karimian, Golnar AD - Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2010 PY - 2010 VL - 7 IS - 4 SP - 247 EP - 251 KW - Captopril KW - Hepatic fibrosis KW - IL-10 KW - TNF-α DO - N2 - Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Objective: The present study was conducted to investigate the effects of captopril on cytokine production in hepatic fibrosis induced by a bile duct ligation model in rats. Methods: Male rats were divided into four groups including; control, sham operated, BDL, and BDL plus captopril (10 mg/kg/day, orally). After 28 days of treatment, the livers were removed for cytokine analysis. Hepatic interleukin (IL)-10 and tumor necrosis factor (TNF)-α levels were measured. Results: Captopril treatment decreased the hepatic content of the proinflammatory cytokine TNF-α and increased the anti-inflammatory cytokine IL-10. Conclusion: the present study suggests that the protective effect of captopril on hepatic fibrosis is likely to be mediated by cytokine production. UR - https://iji.sums.ac.ir/article_17065.html L1 - https://iji.sums.ac.ir/article_17065_073763a79c91a3548a725f7f3f8a88da.pdf ER -