TY - JOUR ID - 33410 TI - The Immunostimulatory Effect of Lactic Acid Bacteria in a Rat Model JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Karamese, Murat AU - Aydin, Hakan AU - Sengul, Emin AU - Gelen, Volkan AU - Sevim, Cigdem AU - Ustek, Duran AU - Karakus, Emre AD - Department of Medical Microbiology, Faculty of Medicine, Kafkas University, Kars AD - Department of Virology, Faculty of Veterinary Medicine AD - Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum AD - Department of Physiology, Faculty of Veterinary Medicine, Kafkas University, Kars AD - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ataturk University, Erzurum AD - Department of Medical Genetics, Faculty of Medicine, Medipol University, Istanbul, Turkey Y1 - 2016 PY - 2016 VL - 13 IS - 3 SP - 220 EP - 228 KW - Bifidobacterium KW - Cytokines KW - Immunomodulation KW - Lactobacillus KW - Probiotics DO - N2 - Background: Probiotics are “live”, beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics. Objective: To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels. Methods: The rats were randomly divided into 4 groups. The first group was “Control group” and other 3 groups were probiotic application groups who received different doses of probiotics. The probiotic mixture included 12 probiotic bacteria, mostly Lactobacillus and Bifidobacterium strains. Probiotic mixture was administered to rats for 12 consecutive days. TNF-α, TGF-β, IL-1-β, IL-6, and IL-10 levels as well as serum IgG and IgA concentrations were detected in the sera after 12 days. Results: Probiotics led to a decrease in the levels of TNF-α, IL-6 and TGF-β; however, they led to increase in the serum levels of IL-10, IgG and IgA. There were significant differences between control group and probiotic application groups (p<0.05). Conclusion: These data suggest that the commensal microbiota are important for stimulating both proinflammatory and regulatory responses in order to rapidly clear infections and minimize inflammation-associated tissue damage. UR - https://iji.sums.ac.ir/article_33410.html L1 - https://iji.sums.ac.ir/article_33410_4bed4d175068f24489cf7a5e48dacf15.pdf ER -