TY - JOUR ID - 39393 TI - Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Zhi, Yue AU - Gao, Peng AU - Li, Wei AU - Zhang, Jie AU - Gao, Fengling AU - Zhang, Jichun AU - Lin, Haitao AD - Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jilin University, AD - Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, China AD - Department of Respiratory, Changchun Center Hospital, Changchun, Jilin, China Y1 - 2018 PY - 2018 VL - 15 IS - 3 SP - 239 EP - 245 DO - 10.22034/iji.2018.39393 N2 - Background: CD163-expressing macrophages are involved in the inflammatory response in asthma. Objective: To assess sputum and serum soluble CD163 (sCD163) and cytokine levels in patients with asthma. Further discussed was the difference between sCD163 and other classic inflammatory mediators. Methods: Sputum was successfully induced in asthma patients (n=85) and healthy controls (n=21). Interleukin (IL)-4, IL-5, IL-1β, IL-8, IL-9, IL-6, and sCD163 levels in sputum were measured. CD163+ monocytes in blood were evaluated using flow cytometry. Results: Sputum sCD163 level significantly increased in asthma (median: 22.4 pg/ml; IQR, 11.52-42.91), unlike healthy controls (10.54 pg/ml;9.85-23.5; P<0.001). Sputum sCD163 (P=0.020) and serum sCD163 (P=0.032) levels were significantly higher in patients with severe asthma compared to those with mild/moderate asthma. Percentage of CD163+ monocytes in patients with asthma was significantly lower than the controls (P<0.001). Conclusion: Increased sCD163 levels in sputum are associated with the impairment of lung function. UR - https://iji.sums.ac.ir/article_39393.html L1 - https://iji.sums.ac.ir/article_39393_ca1518e69b4672fae27fa44fb66d31ac.pdf ER -