TY - JOUR ID - 44943 TI - Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis JO - Iranian Journal of Immunology JA - IJI LA - en SN - 1735-1383 AU - Sağmak Tartar, Ayşe AU - Ozer Balın, Şafak AU - Akbulut, Ayhan AU - Yardım, Meltem AU - Aydın, Suleyman AD - Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey AD - Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey Y1 - 2019 PY - 2019 VL - 16 IS - 2 SP - 182 EP - 189 KW - Brucellosis KW - Dermcidin KW - Salusin-Alpha KW - Salusin-Beta KW - TNF-alpha DO - 10.22034/iji.2019.80261 N2 - Background:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. Methods: From 50 patients hospitalized upon diagnosis of acute brucellosis, blood samples were collected and dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels in serum samples were measured using an ELISA assay. The control group included 40 volunteers. Results: Brucellosis group had significantly lower plasma dermcidin, salusin- alpha, salusin-beta levels compared to the healthy control group (respectively p:0.008, p<0.001, p<0.001). Moreover, Brucellosis group had significantly higher plasma TNF-alpha levels comparisons with the controls (p=0.002). In the examination of the correlation between TNF-alpha and dermcidin, salusin-alpha and salusin-beta in the brucellosis group, only a negative correlation was found between salusin-beta and TNF-alpha. In the control group, there was a positive and statistically significant correlation between salusin-beta and TNF-alpha. Conclusion: Dermcidin, salusin-alpha, and, particularly salusin-beta levels are important in Brucella pathogenesis. The paradoxical correlation between TNF-alpha and salusin-beta in patients with brucellosis and control group is remarkable. However, there is a need for extensive studies conducted with more patients to further elucidate this topic. UR - https://iji.sums.ac.ir/article_44943.html L1 - https://iji.sums.ac.ir/article_44943_b1ffaa006058c56c5c8f5d6be765d2de.pdf ER -