Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages

Eric Adua; Frank Oteng Danso; Oswald Mensah Boa-Amponsem; Frank Adusei-Mensah

Volume 12, Issue 2 , June 2015, , Pages 94-103

Abstract
  Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible ...  Read More

HLA Class I and Class II Genes Distribution of the Sistanis in Iran

mahdi aminikhah; Mir Saeed Yekaninejad; M.Hosein Nicknam; Farideh Khosravi; Mehrnaz naroei nejad; Bita Ansaripour; batol moradi; Behrouz Nikbin; Aliakbar Amirzargar

Volume 15, Issue 2 , June 2018, , Pages 97-111

https://doi.org/10.22034/iji.2018.39374

Abstract
  Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the ...  Read More

Differential Immunogenicity of A Recombinant Hepatitis B Vaccine in Iranian Neonates: Influence of Ethnicity and Environmental Factors

Abdollah Jafarzadeh; Jalal Khoshnoodi; Shayesteh Ghorbani; Saleh Mohaghegh Hazrati; Babak Faraj Mazaheri; Fazel Shokri

Volume 1, Issue 2 , September 2004, , Pages 98-104

Abstract
  Objective: To compare immunogenicity of a recombinant hepatitis B (HB) vaccine in two groups of neonates born in two cities of Iran with different geographic and ethnic backgrounds.   Materials and Methods: Ten micrograms of a recombinant HB vaccine was administered under field condition to Iranian ...  Read More

Antibody Response to Human Extracellular HER2 Subdomain Proteins in Mice

Fateme Sadri-Ardalani; Moslem Ahmadi; Azam Hemmati; Shaghayegh Emami; Samira Farid; Mohammad Mehdi Amiri; Mahmood Jeddi-Tehrani; Mahdi Shabani; Fazel Shokri

Volume 14, Issue 2 , June 2017, , Pages 99-110

Abstract
  Background: In addition to passive immunotherapy using anti-HER2 monoclonal antibodies, active immunotherapy via HER2 targeting is an interesting approach to inducing specific anti-tumor immune responses. We have recently reported the immunogenicity of HER2 subdomains following DNA immunization and HER2 ...  Read More

VEGF-A, HGF and bFGF are involved in IL-17A-mediated migration and capillary-like vessel formation of vascular endothelial cells

Muneo Numasaki; Koyu Ito

Volume 18, Issue 2 , June 2021, , Pages 103-110

https://doi.org/10.22034/iji.2021.91214.2059

Abstract
  Background: Interleukin (IL)-17A possesses biological activities to promote vascular endothelial cell migration and microvessel development. Objective: To clarify which angiogenic factors are involved in IL-17A-modified angiogenesis-related functions of vascular endothelial cell migration and microtube ...  Read More

Iranian Lurs Genetic Diversity: An Anthropological View Based on HLA Class II Profiles

Shirin Farjadian; Abbas Ghaderi

Volume 3, Issue 3 , September 2006, , Pages 106-113

Abstract
  Background: HLA genes are highly polymorphic and certain alleles are frequent only in specific populations. Therefore, HLA is a unique tool for studying the genetic relationship between different populations. Iranians are ethnically diverse people and one of the major ethnic groups in Iran is Lur population ...  Read More

Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer

Mohsen Arabpour; Atri Ghods; Mahmoud Shariat; Abodl-Rasoul Talei; Fereshteh Mehdipour; Abbas Ghaderi

Volume 16, Issue 2 , June 2019, , Pages 108-116

https://doi.org/10.22034/iji.2019.80254

Abstract
  Background: B cells can increase the expression of granzyme B in CD8+ T cells through 4-1BBL/4-1BB interaction and promote anti-tumor immunity. Objective: To investigate the expression of 4-1BBL on B cells in the breast tumor draining lymph nodes (TDLNs) and its association with disease parameters. Methods: ...  Read More

Toward an Alum Free Mono-Component Monovalent Pertussis Vaccine: A Cytokine Response Assay

Hossein Forghani; Mahin Jamshidi Makiani; Hossein Zarei Jaliani; Seyed Mohsen Zahraei; Seyedeh Mahdieh Namayandeh; Parisa Khani

Volume 17, Issue 2 , June 2020, , Pages 111-120

https://doi.org/10.22034/iji.2020.86199.1749

Abstract
  Background: Currently evidence indicates the resurgence of whooping cough despite high coverage of whole-cell (wP) and acellular (aP) pertussis vaccines. Objective: In this study, we investigated the cell-mediated immune response of a genetically inactivated protein containing the S1 subunit of pertussis ...  Read More

Vascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms

Mojgan Mohammadi; Mohammad Reza Bazrafshani; Philip.J Day; William. E.R. Ollier

Volume 6, Issue 3 , September 2009, , Pages 119-129

Abstract
  Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 ...  Read More

Construction of a Eukaryotic Plasmid Encoding Bacillus anthracis Protective Antigen, a Candidate for DNA Vaccine

Fatemeh Vahedi; Naser Taiebi Meibody; Mahdi KianiZadeh; Mahmoud Mahmoudi

Volume 2, Issue 3 , September 2005, , Pages 134-140

Abstract
  Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. Objective: To evaluate the use of a DNA immunization strategy for protection against anthrax, a plasmid was constructed. Methods: The partialsequence ...  Read More

Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo

Maryam Azimi Mohamadabadi; Zuhair Mohammad Hassan; Ahmad Zavaran Hosseini; Mehrdad Gholamzad; Shekoofe Noori; Mehdi Mahdavi; Hamidreza Maroof

Volume 10, Issue 3 , September 2013, , Pages 139-149

Abstract
  Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells. Objective: To investigate the cytotoxic ...  Read More

Association Between Polymorphisms of IL-23/IL-17 Pathway and Clinical Phenotypes of Autoimmune Thyroid Diseases

Tiantian Cai; Guofei Wang; Yanping Yang; Kaida Mu; Jing Zhang; Yanfei Jiang; Jin-an Zhang

Volume 19, Issue 2 , June 2022, , Pages 139-149

https://doi.org/10.22034/iji.2022.93744.2255

Abstract
  Background: Several autoimmune and inflammatory disorders, including autoimmune thyroid diseases (AITD), have been linked to Th17 cells and the IL-23/IL-17 axis. Current data suggest that genetic variation contributes greatly to disease susceptibility to AITD. Objectives: To study the role ...  Read More

Candida albicans Structural and Secreted Proteins Modulate CD4/CD8 Ratio in Tumor Infiltrating Lymphocytes of Spontaneous Adenocarcinoma Bearing Mice

Marzieh Holakuyee; Mohammad Hossein Yadegari; Zuhair Mohammad Hassan; Mansour Bayat; Ariyo Shahin Jafari; Mohsen Abolhassani; Abbas Ali Amini; Mehdi Mahdavi

Volume 7, Issue 3 , September 2010, , Pages 142-149

Abstract
  Background: Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer. Objective: To evaluate the effects of C. albicans structural ...  Read More

Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia

Ali Memarian; Mahmood Jeddi Tehrani; Parvaneh Vossough; Ramazan Ali Sharifian; Hodjatallah Rabbani; Fazel Shokri

Volume 4, Issue 3 , December 2007, , Pages 145-154

Abstract
  Background: Wnt molecules play a key role in growth, proliferation and development of some embryonic and adult organs as well as hematopoietic stem cells. Wnt signaling pathways are aberrantly activated in many tumor types, including solid tumors and hematologic malignancies. Objective: To investigate ...  Read More

Cloning, Expression and Purification of Truncated Chlamydia Trachomatis Outer Membrane Protein 2 (Omp2) and its Application in an ELISA Assay

Bahram Kazemi; Negar Seyed; Mojgan Bandehpour; Zarrin Sharifnia; Parviz Pakzad

Volume 5, Issue 3 , September 2008, , Pages 148-155

Abstract
  Background: Although a simple and direct method does not exist for the detection of chlamydial infections, there are situations in which reliable serological tests, with sensi-tivity related to a specific antigen, could be helpful. Objective: The aim of this study was to clone the first 1100 bp of the ...  Read More

Validation of a β-ME ELISA for Detection of Anti Leishmania donovani Antibodies in Eastern Sudan

Elfadil Abass; Abdelhafeiz Mahamoud; Durria Mansur; Mehdi Mohebali; Abdollah el Harith

Volume 8, Issue 3 , September 2011, , Pages 150-158

Abstract
  Background: A β-mercaptoethnol (β-ME)-treated promastigote antigen of L. donovani was successfully employed in direct agglutination test (DAT) for the diagnosis of visceral leishmaniasis (VL). Objective: The β-ME-treated antigen was further incorporated into an enzyme-linked immunosorbent ...  Read More

Maturation State and Function of Monocyte Derived Dendritic Cells in Liver Transplant Recipients

Afsoon Shariat; Mohammad Hossein Karimi; Talat Mokhtariazad; Seyed Mohammad Moazzeni; Bita Geramizadeh; Seyed Ali MalekHosseini; Ramin Yaghobi

Volume 11, Issue 3 , September 2014, , Pages 153-165

Abstract
  Background: Dendritic cells (DCs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. These cells are centrally involved in the initiation of T cell-dependent immune responses. Objective: To compare the level of DC maturation and function in liver transplant ...  Read More

Measurement of Affinity Constant of Anti-human IgG Monoclonal Antibodies by an ELISA-based Method

Fatemeh Hajighasemi; Ali Akbar Saboor-Yaraghi; Fazel Shokri

Volume 1, Issue 3 , December 2004, , Pages 154-161

Abstract
  Background: The affinity of an antibody to its antigen is a crucial parameter in its biological activity and performance of an immunoassay such as ELISA. Affinity of most IgG specific MAbs are often determined by methods which require labeling of either antigen or antibody, and are sometimes difficult ...  Read More

Expression of VLA1, VLA2 and VLA3 Integrin Molecules in Uterine Endometrium of Infertile Women with Unexplained Aetiology in Ahwaz-Iran

Mehri Ghafourian Boroujerdnia; Fatemeh Ghalambor Dezfuly; Nepton Emad Mosthophy; Rahim Chinipardaz

Volume 3, Issue 4 , December 2006, , Pages 157-163

Abstract
  Background: Recent attention has focused on the expression of integrin molecules within the endometrium, and their relation to infertility. Objective: The present prospective study was undertaken to determine whether the endometrium of women with unexplained infertility differs in the expression of very ...  Read More

Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches

Alireza Rafiei; Mahoud Abedini; Seyed Hamzeh Hosseini; Zahra HosseiniKhah; Behrouz Bazrafshan; Mohsen Tehrani

Volume 9, Issue 3 , September 2012, , Pages 159-167

Abstract
  Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed ...  Read More

Teucrium polium Extract Attenuates Inflammation in Asthma by Reducing RORγt Transcription and Increasing IL-10 Secretion in an Ovalbumin-induced Murine Asthma Model

Shole Daneshvar-ghahfarokhi; Amir Rahnama; Vahid Mohammadi-Shahrokhi

Volume 20, Issue 2 , June 2023, , Pages 159-166

https://doi.org/10.22034/iji.2023.97422.2509

Abstract
  Background: One of the inflammatory diseases of the respiratory system is asthma. Teucrium polium (TP) has anti-inflammatory and anti-allergic properties and its anti-asthmatic effects have not been investigated yet. RORγt is an inflammatory transcription factor for Th17 differentiation. By secreting ...  Read More

Patients with Active Rheumatoid Arthritis Have Lower Frequency of nTregs in Peripheral Blood

Hamid-Reza Zare; Mojtaba Habibagahi; Akbar Vahdati; Zahra Habibagahi

Volume 12, Issue 3 , September 2015, , Pages 166-175

Abstract
  Background: Patients with rheumatoid arthritis (RA) suffer from wide ranges of autoimmune reactions in joints. The mechanism of which is generally unknown and maybe associated with Treg deregulation. Objective: To compare the frequency of nTregs in peripheral blood of patients with active rheumatoid ...  Read More

Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer

Hamideh Mesali; Abolghasem Ajami; Hadi Hussein-Nattaj; Alireza Rafiei; Zeinab Rajabian; Hossein Asgarian-Omran; Vahid Hosseini; Tarang Taghvaei; Mohsen Tehrani

Volume 13, Issue 3 , September 2016, , Pages 167-177

Abstract
  Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were ...  Read More

Heterologous Immunization, a Way out of the Problem of Monoclonal Antibody Production against Carcinoma Antigen 125

Sorour Shojaeian; Amir Hassan Zamani; Mahmood Jeddi-Tehrani; Forouzandeh Fereidooni; Ebrahim Torkabadi; Mohammad Mehdi Akhondi; Akram Sadat Tabatabaei-Panah; Abdolamir Allameh

Volume 6, Issue 4 , December 2009, , Pages 174-185

Abstract
  Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization ...  Read More

T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome

Fatemeh Nasri; Mehrnoosh Doroudchi; Bahia Namavar Jahromi; Behrouz Gharesi-Fard

Volume 15, Issue 3 , September 2018, , Pages 175-185

https://doi.org/10.22034/iji.2018.39387

Abstract
  Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper ...  Read More