Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)

Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19

Amir Hossein Norooznezhad; Alireza A Shamshirsaz; Sedigheh Hantoushzadeh

Volume 19, Issue 3 , September 2022, , Pages 330-336

https://doi.org/10.22034/iji.2022.93951.2267

Abstract
  Pregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the general population. Possible pathways are: I) in patients with COVID-19, cytokine storm defined as the excess release of pro-inflammatory cytokines such as interleukin 1β (IL-1β), ...  Read More

More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients

German Reynaldo Jiménez-Gastélum; Arely Monserrant Espinoza-Ortega; Rosalío Ramos-Payán; Maribel Aguilar-Medina; Jorge López-Gutiérrez; Carlos Villegas-Mercado; Luis Antonio Ochoa-Ramirez; Horacio Rendón-Aguilar; Juan Fidel Osuna-Ramos; Juan José Ríos-Tostado; Jesús Salvador Velarde-Félix

Volume 18, Issue 4 , December 2021, , Pages 331-337

https://doi.org/10.22034/iji.2021.89905.1978

Abstract
  Background: According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavirus disease 2019 (COVID-19). The "cytokine storm" phenomenon has been proposed as a pathological hallmark of severe COVID-19. Objective: To determine the association of serum cytokine ...  Read More

SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway

Wenfei Gu; GuangTao Qi; Li Chen

Volume 20, Issue 3 , September 2023, , Pages 335-347

https://doi.org/10.22034/iji.2023.98236.2559

Abstract
  Background: Spi-B transcription factor (SPIB) is an E-twenty-six (ETS) transcription factor associated with tumor immunity.Objective: To investigate the functions and mechanisms of SPIB in ovarian cancer (OC) cells.Methods: Cell proliferation, apoptosis, migration, and invasion were determined using ...  Read More

Letter to the Editor Regarding "An Overview on Serology and Molecular Tests for COVID-19: An Important Challenge of the Current Century (doi: 10.22034/iji.2021.88660.1894.)"

Milad Zandi; Emad Behboudi; Mohammad Reza Shojaei; Saber Soltani; Hassan Karami

Volume 19, Issue 3 , September 2022, , Pages 337-337

https://doi.org/10.22034/iji.2022.91791.2107

Abstract
  Recently in a review article by Mansourabadi et al. published in the Iranian Journal of Immunology, the authors described the serological and molecular tests for COVID-19 (1). The mentioned review considered helicase (Hel) as a structural protein of SARS-CoV-2 (1). However, based on evidence, the genome ...  Read More

Evaluation of the Relationship between Pro-Inflammatory Cytokine Levels and Clinical Findings of Fibromyalgia Syndrome

Pınar Ellergezen; Alev ALP; Sinan Çavun

Volume 18, Issue 4 , December 2021, , Pages 338-345

https://doi.org/10.22034/iji.2021.90539.2013

Abstract
  Background: Immune system has an important effect on pain-related disorders such as fibromyalgia syndrome (FMS). There is no specific laboratory technique for the diagnosis of FMS, but measuring serum proinflammatory cytokines may help. Objective: The purpose of our study was to determine the serum levels ...  Read More

Evaluation of Innate Lymphoid Cells (ILCs) Population in the Mouse Model of Colorectal Cancer

Seyed Mohammad Javadzadeh; Mohsen Keykhosravi; Mohsen Tehrani; Hossein Asgarian-Omran; Mohsen Rashidi; Hadi Hossein-Nattaj; Laleh Vahedi-Larijani; Abolghasem Ajami

Volume 19, Issue 4 , December 2022, , Pages 339-348

https://doi.org/10.22034/iji.2022.92467.2152

Abstract
  Background: Innate Lymphoid Cells (ILCs) promote tissue homeostasis, contribute to the immune defense mechanisms, and play important roles in the initiation of immune responses and chronic inflammation. Objective: To understand the roles of innate lymphoid cells in the pathophysiology of colorectal ...  Read More

Elevated IL-37 Serum Levels in Patients with Transitional Cell Carcinoma of Bladder

Mohammad Reza Haghshenas; Seyed Reza Hosseini; Mohammad Javad Fattahi; Mahyar Malekzadeh; Ali Ariafar; Abbas Ghaderi

Volume 18, Issue 4 , December 2021, , Pages 346-353

https://doi.org/10.22034/iji.2021.92669.2167

Abstract
  Background: Interleukin-37 (IL-37) is a recently described cytokine that emerges as a natural inhibitor of inflammatory and immune responses. However, IL-37 has not yet been investigated in bladder cancer, and its biological role is unknown. Objective: The purpose of this study was to investigate IL-37 ...  Read More

Impact of Echinococcus granulosus Antigens on Monocyte Development and Dendritic Cell Differentiation

Mingxia Wang; Fei Qiao; Zihua Li; Qiang Wang; Zailing Shang; Junhu Hei; Xuelin Ma; Yana Wang

Volume 20, Issue 3 , September 2023, , Pages 348-358

https://doi.org/10.22034/iji.2023.98163.2557

Abstract
  Background: Different subtypes of dendritic cells (DCs) can induce different types of immune responses. Our previous study found that Echinococcus granulosus (E. granulosus) antigens (Eg.ferritin, Eg.mMDH and Eg.10) stimulated DC differentiation to different subtypes and produced different immune responses.Objective: ...  Read More

LncRNA-GAS5 and its Promoter Region Polymorphism Associate with Helper Th17 Polarization and Predict Postoperative Pain and the Prognosis of the Patients with Hepatocellular Carcinoma Undergoing Hepatectomy

Zhanming Sha; Panpan Zhang

Volume 19, Issue 4 , December 2022, , Pages 349-357

https://doi.org/10.22034/iji.2022.92678.2168

Abstract
  Background: The relationship between genetic polymorphism and postoperative pain and the prognosis of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy is not fully understood. Objective: To examine whether lncRNA-GAS5 and its promoter region rs145204276 polymorphism can predict ...  Read More

Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis

Maja Stojanovic; Zorana Andric; Dusan Popadic; Marija Stankovic Stanojevic; Rada Miskovic; Dragana Jovanovic; Aleksandra Peric Popadic; Jasna Bolpacic; Vesna Tomic-Spiric; Sanvila Raskovic

Volume 18, Issue 4 , December 2021, , Pages 354-365

https://doi.org/10.22034/iji.2021.88846.1911

Abstract
  Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic characteristics, and potential significance in prognosis. ...  Read More

Identification of the CD16low CD56low CD38pos Natural Killer Cell as a Key Subset in Patients with Multiple Myeloma

Ting Chen; Zhenghong Yu

Volume 19, Issue 4 , December 2022, , Pages 358-368

https://doi.org/10.22034/iji.2022.93965.2269

Abstract
  Background: Natural killer (NK) cells are classified as innate immune cells which can directly recognize and kill tumor cells without antigen sensitization. NK cell-based adoptive immunotherapy for blood malignancies has attracted more attention in recent years. Objective: To analyze different NK ...  Read More

Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D

Mahnaz Bayat; Niloufar Razavi Moosavi; Najmeh Karimi; Moosa Rahimi; Afshin Borhani-Haghighi

Volume 20, Issue 3 , September 2023, , Pages 359-367

https://doi.org/10.22034/iji.2023.96384.2432

Abstract
  Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) is a pro-inflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders.Objective: To investigate the levels of IL-1β and vitamin D (VitD) ...  Read More

Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease

Zivar Zangeneh; Gholamreza Khamisipour

Volume 20, Issue 3 , September 2023, , Pages 368-373

https://doi.org/10.22034/iji.2023.97202.2488

Abstract
  Background: Heat shock proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory responses due to immune cell activation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was one of the most important causes of death in the recent pandemic. Increased cellular ...  Read More

Evaluation of CD3+ T Cell Percentage, Function and its Relationship with Serum Vitamin D Levels in Women with Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Abdolah Mousavi Salehi; Mehri Ghafourian; Afshin Amari; Mahvash Zargar

Volume 19, Issue 4 , December 2022, , Pages 369-377

https://doi.org/10.22034/iji.2022.91464.2083

Abstract
  Background: Women afflicted with recurrent spontaneous abortion (RSA) and repeated implantation failure (RIF) may have immune abnormalities. The role of vitamin D has been demonstrated in the function of the immune system. Objective: To assess the percentage and function of CD3+ T cells and their ...  Read More

Evaluation of SARS-CoV-2 Specific Antibodies in Recovered Patients by Different ELISA Kits

Alireza Fereidouni; Hamidreza Safari; Hadis Rezapoor; Sara Mahmoudzadeh; Mohammad Fereidouni

Volume 20, Issue 3 , September 2023, , Pages 374-381

https://doi.org/10.22034/iji.2023.93206.2202

Abstract
  Background: The coronavirus disease 2019 (COVID-19) was first reported in December 2019 in Wuhan, Hubei Province of China. As long as the 27th of December 2021, approximately 280 million people have been infected with coronavirus, resulting in more than 5,418,421 deaths worldwide. Since the beginning ...  Read More

Changes in Maternal Serum Levels of C3 and C4 Complement Components in Different Delivery Methods and Postpartum Hemorrhage

Guangxia Cui; Tingyue Zhang; Hongjiang Tian; Hui Zhang; Jin Zhang; Xi Wang; Xiaoyan Zhang; Wenpei Bai

Volume 19, Issue 4 , December 2022, , Pages 378-384

https://doi.org/10.22034/iji.2022.93655.2242

Abstract
  Background: Activation of the complement system may play a role in the pathophysiology of human labor. Yet no unanimous conclusion has been drawn. Objective: To compare the differences in maternal complement components C3 and C4 serum levels in cesarean section and the vaginal delivery at term and ...  Read More

Enzyme-Assisted Extraction of Narirutin from Citri Reticulatae Pericarpium and Anti-allergic Asthma Activity

Xiaolei Shi; Lina Zhao; Liyan Niu; Jhao Wei; Xuwen Li; Yongri Jin

Volume 19, Issue 4 , December 2022, , Pages 385-394

https://doi.org/10.22034/iji.2022.91640.2095

Abstract
  Background: Asthma is a heterogeneous disorder of the airways related to inflammation; it affects millions of people worldwide. Due to the side effects of inhaled corticosteroids, researchers focused on the therapeutic effects of compounds derived from natural products. Objective: To investigate the ...  Read More

Predictive Value of the Serum Diamine Oxidase Level in the Diagnosis of Seasonal Allergic Rhinitis

Ali Aghili; Ahmad Rezaeian

Volume 19, Issue 4 , December 2022, , Pages 395-403

https://doi.org/10.22034/iji.2022.95336.2358

Abstract
  Background: Allergic rhinitis (AR) is characterized by the increased sensitivity of the nasal mucosa to allergens and has a significant impact on life quality. There is promising evidence that biomarkers can help in the diagnosis, treatment, and follow-up of patients with AR. Diamine oxidase (DAO) ...  Read More

The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients

Masumeh Darai; Saeede Soleimanian; Ramin Yaghobi; Kourosh Kazemi; Saman Nikeghbalian; Negar Azarpira

Volume 19, Issue 4 , December 2022, , Pages 404-413

https://doi.org/10.22034/iji.2022.95345.2359

Abstract
  Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important roles in immunity to viruses. The 14bp insertion/deletion ...  Read More

Niclosamide Modulates the Cellular and Humoral Immune Response in Balb/c Mice

Bilal Mahmood Beg; Aqeel Javeed; Muhammad Ashraf; Arfan Ahmad; Adeel Sattar; Mehmood Ahmad

Volume 19, Issue 4 , December 2022, , Pages 414-426

https://doi.org/10.22034/iji.2022.90653.2022

Abstract
  Background: Niclosamide, a STAT3 inhibitor, is widely under investigation due to its anti-cancer properties. STAT3 also exhibits an exciting role in the immune responses. Objective: This study aimed to evaluate the impact of niclosamide on immune response of mice. Methods: Niclosamide was administered ...  Read More

The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis

Mehrdad Shavandi; Yasaman Yazdani; Shirin Asar; Arash Mohammadi; Ehsan Mohammadi-noori; Amir Kiani

Volume 19, Issue 4 , December 2022, , Pages 427-435

https://doi.org/10.22034/iji.2022.90456.2007

Abstract
  Background: Rheumatoid Arthritis (RA) is a systemic chronic autoimmune disease. Several inflammatory agents play key roles in RA pathogenesis, among which tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) are of great importance. Silymarin is a potent anti-oxidant extracted ...  Read More

Introducing a New Method for Purification of Human IL-4 by Substitution of a Single Amino Acid in IL-4 Protein Sequence

Mohsen Mazloomrezaei; Mahsa Sadat Hosseini; Nahid Ahmadi; Elham Mahmoudi Maymand; Ebrahim Eftekhar; Amir Asgari; Amin Ramezani

Volume 19, Issue 4 , December 2022, , Pages 436-445

https://doi.org/10.22034/iji.2022.94985.2336

Abstract
  Background: It is advantageous to develop an effective purification procedure to produce recombinant protein drugs (rPDs) without any tags. To remove N- or C-terminus tags from the rPDs, several cleavage site-based endopeptidases were used. Separating the endopeptidase enzyme from the rPDs is a time-consuming ...  Read More