Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

Document Type: Original Article

Authors

1 Department of Histology, Medical School, Ahwaz Jondishapour University of Medical Sciences (AJUMS), Ahwaz, Iran

2 Department of Pathology, Medical School, Edinburgh University, Edinburgh, Scotland, UK

Abstract

Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.  
Objective:
In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.  
Methods:
Using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of Galectin-3 in normal and OA human articular cartilage were assessed.  
Results:
Immunohistochemical studies showed a similar pattern of Galectin-3 expression in normal and mild OA but severe OA showed different strong expression in all zones of human articular cartilage.  
Conclusion:
Increased expression pattern of Galectin-3 in advanced stages of OA may occur as a result of the imbalance of chondrocyte homeostasis that occurs in OA cartilage and provides a condition to modify normal chondrocyte to an OA chondroctye.

Keywords