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Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model

Afshin Namdar; Hamid Reza Mirzaei; Farhad Jadidi-Niaragh; Mahboubeh Ashourpour; Maryam Ajami; Jamshid Hadjati; Abbas Rezaei

Volume 12, Issue 3 , September 2015, , Pages 176-187

Abstract
  Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid ...  Read More