Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Masoumeh Varedi

Volume 2, Issue 2 , June 2005, , Pages 67-77

Abstract
  Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological ...  Read More

Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Magdy Mohamed Zedan; Amal Mohamed Osman; Wafaa Nabil Laimon; Mohamed Magdy Zedan; Nermin Youssef Abo-elkheir; Ahmed Zaki

Volume 13, Issue 2 , June 2016, , Pages 70-88

Abstract
  Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active ...  Read More

Emerging Role of Uterine Natural Killer Cells in Establishing Pregnancy

Vijay Kumar; Bikash Medhi

Volume 5, Issue 2 , June 2008, , Pages 71-81

https://doi.org/10.22034/iji.2008.48555

Abstract
  Normal pregnancy has been considered as a controlled state of inflammation at an early stage of blastocyst implantation that subsequently develops systemically. Till recent past most popular hypotheses regarding status of immune system in pregnancy were dominated by the Th1 and Th2 hypothesis, in which ...  Read More

Revisiting Beta 2 Glycoprotein I, the Major Autoantigen in the Antiphospholipid Syndrome

Soheila Rahgozar

Volume 9, Issue 2 , June 2012, , Pages 73-85

Abstract
  Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI ...  Read More

Vaccination with Live Attenuated L. Major and TLR4 Agonist Promotes a Th1 Immune Response and Induces Protection against L. Major Infection in BALB/c Mice

Shamsi Noorpisheh Ghadimi; Shirin Farjadian; Gholam Reza Hatam; Mehdi Kalani; Bahador Sarkari

Volume 15, Issue 2 , June 2018, , Pages 74-83

https://doi.org/10.22034/iji.2018.39372

Abstract
  Background: Toll like receptors play a major role in immune responses against Leishmania parasites. Objective: To evaluate the efficacy of vaccination with live attenuated L. major and TLR4 agonist in protection against L. major infection. Methods: Attenuated L. major was prepared by continuous sub-culturing ...  Read More

Role of Immunosuppression Minimization Protocols in Renal Transplantation

Nasrollah Ghahramani

Volume 1, Issue 2 , September 2004, , Pages 78-96

Abstract
  The subject of transplant immunosuppression has generated significant interest in recent years. Excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. There is widespread support for the notion that the fundamental ...  Read More

Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T Helper 17 Cells and Related Cytokines in Systemic Lupus Erythematosus

Hadi Reihani; Maryam Rastin; Mahmoud Mahmoudi; Mohsen Ghoryani; Nafiseh Abdollahi; Nafiseh Sadat Tabasi; Shahrzad Zamani Taghizadeh Rabe; Maryam Sahebari

Volume 12, Issue 2 , June 2015, , Pages 82-93

Abstract
  Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) ...  Read More

Anti-inflammatory Effects of PMX205 in Mouse Macrophage Periodontitis Model

Gege Li; Jiahui Pan; Qiuling Tang; Xinchan Liu; Liuran Wang; Yang Meng; Weixian Yu

Volume 15, Issue 2 , June 2018, , Pages 84-96

https://doi.org/10.22034/iji.2018.39373

Abstract
  Background: C5areceptor antagonistPMX205 is a synthetic hexapeptidecapable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a myriad inflammation models. The anti-inflammatory effect of PMX205 ...  Read More

Prognostic Impact of Circulating CD28 Negative Suppressor T Cells and Memory B Cells on Treatment Outcomes of Patients with Breast Cancer

Asmaa M. Zahran; Asmaa S. Shaltout; Hussein Fakhry; Ola N. Abdel Fattah; Doaa F. Temerik; Salah M. Khalaf; Amal Rayan

Volume 17, Issue 2 , June 2020, , Pages 95-110

https://doi.org/10.22034/iji.2020.83420.1625

Abstract
  Background: It has been suggested that routine assessment and quantification of different lymphocyte subsets can provide clinically meaningful prognostic information in breast cancer (BC). Objective: To determine the relationship between peripheral blood lymphocyte subsets and pathological parameters ...  Read More

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Fatemeh Mashhadi-Abbas; Masoume Fayazi_Boroujeni; Akram Alizadeh; Mahshid Namdari; Seyed Abbas Mirzaei

Volume 18, Issue 2 , June 2021, , Pages 95-102

https://doi.org/10.22034/iji.2021.87031.1782

Abstract
  Background: The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear. Objective: This ...  Read More

Pathogenesis of Atopic Dermatitis: Current Paradigm

Masutaka Furue; Dugarmaa Ulzii; Yen Vu; Gaku Tsuji; Makiko Kido-Nakahara; Takeshi Nakahara

Volume 16, Issue 2 , June 2019, , Pages 97-107

https://doi.org/10.22034/iji.2019.80253

Abstract
  Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles ...  Read More

Dendritic Cell Maturation with CpG for Tumor Immunotherapy

Samaneh Arab; Masoumeh Motamedi; Nematollah Khansari; Seied Mohammad Moazzeni; Zahra Gheflati; Jamshid Hadjati

Volume 3, Issue 3 , September 2006, , Pages 99-105

Abstract
  Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen ...  Read More

Immediate Exposure to TNF-α Activates Dendritic Cells Derived from Non-Purified Cord Blood Mononuclear Cells

Marzieh Ebrahimi; Zuhair Mohammad Hassan; Jamshid Hadjati; Parisa Hayat; Seyed Mohammad Moazzeni

Volume 6, Issue 3 , September 2009, , Pages 107-118

Abstract
  Background: Tumor necrosis factor alpha (TNF-α) is a primary mediator of immune regulation and might be required in the early stages of DC development from CD34+ cells. However, details of optimal timing of exposure to TNF-α in DC development process in monocytes or non-purified hematopoitic ...  Read More

Essential Transcription Factors and Functional Roles of Follicular Helper T Cells in Human Autoimmune Diseases

Sara Iranparast; Farhad Seif; Sanaz Tayebi; Farhad Abolnezhadian; Moosa Sharifat; Alireza Fazaeli; Neda Roshanravan; Azam Samei; Sholeh Khajoei

Volume 19, Issue 2 , June 2022, , Pages 121-138

https://doi.org/10.22034/iji.2022.92653.2164

Abstract
  Follicular helper T (TFH) cells are a subset of effector CD4+ T cells that support the differentiation of antigen-specific B cells in the germinal center. TFH cells are distinct from other established CD4+ T cell subsets and possess a list of transcription factors, including BCL6, IRF4, c-Maf, Batf, ...  Read More

Production and Characterization of Murine Monoclonal Antibodies Recognizing Conformational and Linear Epitopes Localized on Human IgA2 Molecules

Fatemeh Hajighasemi; Soheila Gharagozlou; Nasrin Moheghi; Roya Ghods; Jalal Khoshnoodi; Fazel Shokri

Volume 2, Issue 3 , September 2005, , Pages 125-133

Abstract
  Background: There are two subclasses of human IgA (IgA1 and IgA2) that differ in antigenic properties and in chemical composition. The constant domains of α1 and α2 heavy chains have >95% sequence homology though major structural differences exist in the hinge region. Quantitation of IgA ...  Read More

Construction and Expression of Hepatitis B Surface Antigen Escape Variants within the "a" Determinant by Site Directed Mutagenesis

Forough Golsaz Shirazi; Mohammad Mehdi Amiri; Hamed Mohammadi; Ali Ahmad Bayat; Azam Roohi; Jalal Khoshnoodi; Amir Hassan Zarnani; Mahmood Jeddi-Tehrani; Gholam Ali Kardar; Fazel Shokri

Volume 10, Issue 3 , September 2013, , Pages 127-138

Abstract
  Background: The antibody response to hepatitis B surface antigen (HBsAg) controls hepatitis B virus infection. The "a" determinant of HBsAg is the most important target for protective antibody response, diagnosis and immunoprophylaxis. Mutations in this area may induce immune escape mutants and affect ...  Read More

CTLA4 Gene Variants in Autoimmunity and Cancer: a Comparative Review

Abbas Ghaderi

Volume 8, Issue 3 , September 2011, , Pages 127-149

Abstract
  Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, ...  Read More

Dendritic Cells and Their Role in Cancer Immunotherapy

Ahmad Jalili

Volume 4, Issue 3 , December 2007, , Pages 127-144

Abstract
  Dendritic cells (DCs) are antigen presenting cells with unique capability to take up and process antigens in the peripheral blood and tissues. They subsequently migrate to draining lymph nodes where they present these antigens and stimulate naive T lympho-cytes. During their life cycle, DCs go through ...  Read More

Brucella abortus L7/L12 Recombinant Protein Induces Strong Th1 Response in Acute Brucellosis Patients

Esra Kazak; Sergio Costa Oliveria; Güher Goral; Halis Akalin; Emel Yilmaz; Yasemin Heper; Haluk Barbaros Oral

Volume 7, Issue 3 , September 2010, , Pages 132-141

Abstract
  Background: Because of high morbidity of the brucellosis in humans and the potential use of the microorganism as an agent of biologic warfare, protection of effective vaccines and specific diagnostic reagents become necessary to eradicate brucellosis. Objective: In this study we aimed to investigate ...  Read More

Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction

Sara Assadiasl; Pedram Ahmadpoor; Mohsen Nafar; Mahboob Lessan Pezeshki; Fateme Pourrezagholi; Mahmoud Parvin; Abtin Shahlaee; Adel Sepanjnia; Mohammad Hossein Nicknam; Aliakbar Amirzargar

Volume 11, Issue 3 , September 2014, , Pages 139-152

Abstract
  Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic ...  Read More

Indoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy

Amir Hassan Zarnani; Pouneh Dokouhaki; Mahmood Jeddi-Tehrani

Volume 1, Issue 3 , December 2004, , Pages 143-153

Abstract
  Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense ...  Read More

LKB1 Positively Regulates Dendritic Cell-induced T Cell Immunity and Suppresses Tumor Development

Wenjie Zhang; Shan Liu; Lin Zhao; Juncheng Wang; Meng Liu; Fengge Wang; Yuekang Xu

Volume 20, Issue 2 , June 2023, , Pages 145-158

https://doi.org/10.22034/iji.2023.96163.2412

Abstract
  Background: The functions of dendritic cells (DCs) are influenced by their intracellular metabolism, in which liver kinase B1 (LKB1) plays an important role. However, due to the difficulty in isolating the DCs, the roles of LKB1 in DC maturation and functions in tumor settings have been poorly characterized.Objective: ...  Read More

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15

Abdolkarim Sheikhi; Abdollah Jafarzadeh; Parviz Kokhaei; Mohammad Hojjat-Farsangi

Volume 13, Issue 3 , September 2016, , Pages 148-166

Abstract
  Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently ...  Read More