Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir

yunlong zhuang; xixi li; huicong xu; hui ye; di sun; xiangzhng liu; Guijie Ren

Volume 15, Issue 2 , June 2018, , Pages 112-121

https://doi.org/10.22034/iji.2018.39375

Abstract
  Background: Entecavir (ETV) is commonly used to treat chronic hepatitis B (CHB) in China. However, certain percentages of e-Antigen (HBeAg) positive CHB patients do not respond to ETV therapy. Objective: To investigate whether the killer immunoglobulin-like receptor (KIR) genes were associated with seroconversion ...  Read More

Immune Response Following Oral Immunization with BCG Encapsulated in Alginate Microspheres

Faramarz Dobakhti; Soheila Ajdari; Mohammad Taghikhani; Shahnaz Rafiei; Khosrow Bayati; Mortez Rafiee-Tehrani

Volume 3, Issue 3 , September 2006, , Pages 114-120

Abstract
  Background: Different methods have been used for BCG vaccination. Alginate microspheres are useful in delivery of vaccines to the gastrointestinal tract by oral route. Objective: To compare the immune response following oral microencapsulated and subcutaneous (SC) route administration of BCG vaccine ...  Read More

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients

Hadi Hossein-Nataj; Mohsen Masjedi; Mohammad Hassan Emami; Mojgan Mokhtari; Fereshteh Alsahebfosoul

Volume 16, Issue 2 , June 2019, , Pages 117-126

https://doi.org/10.22034/iji.2019.80255

Abstract
  Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac ...  Read More

In-Silico Analysis and Protective Efficacy of the PcrV Recombinant Vaccine against Pseudomonas Aeruginosa in the Burned and PA-Infected BALB/c Mouse Model

Mohammad Hadi Fakoor; Parviz Owlia; Seyed Latif Mousavi gargari; Azar Sabokbar

Volume 17, Issue 2 , June 2020, , Pages 121-136

https://doi.org/10.22034/iji.2020.85590.1718

Abstract
  Background: Pseudomonas aeruginosa is considered as the most severe cause of infections in burn patients and pneumonia infections. Objective: To study the protective effects of recombinant protein vaccine harboring the PcrV of P. aeruginosa in the mouse model of burn and respiratory infections. Methods: ...  Read More

Glutathione S-transferases Null Genotype in Acute Myeloid Leukaemia

Mohammad Hasan Sheikhha; Mehdi Kalantar; Khalid Tobai; John A. Liu Yin

Volume 2, Issue 3 , September 2005, , Pages 141-151

Abstract
  Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated ...  Read More

KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease

Elham Ashouri; Mohammad Hossein Dabbaghmanesh; Amirhossein Hadaegh; Soodeh Rowhanirad; Marizeh Bakhshayeshkaram; Gholamhossein Ranjbar Omrani

Volume 10, Issue 3 , September 2013, , Pages 150-157

Abstract
  Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility ...  Read More

The Use of Crude Plasmodium falciparum Antigens for Comparison of Antibody Responses in Patients with Mild Malaria vs. Cerebral Malaria

Babacar Mbengue; Birahim Niang; Bacary Diatta; Adama Tali; Olivier Garraud; Ronald Perraut; Alioune Dieye

Volume 7, Issue 3 , September 2010, , Pages 150-161

Abstract
  Background: Cerebral malaria (CM) is one of the major causes of death in African populations infected with Plasmodium falciparum. Only 1% of infected subjects develop CM. The reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens ...  Read More

Vitamin D Reduces the Helper T Cells 17 (Th17) Differentiation in Patients with Ulcerative Colitis by Targeting Long Non-coding RNA (lncRNA) OIP5-AS1/miR-26a-5p/IL-6 Axis

Chaohui Zhu; Min Fan; Jianhua Zhu; Limin Cao; Xinyu Duan; Kai Wu

Volume 19, Issue 2 , June 2022, , Pages 150-160

https://doi.org/10.22034/iji.2022.90562.2014

Abstract
  Background: Vitamin D has anti-inflammatory efficacy against ulcerative colitis (UC), however, the mechanism is yet little understood. Objective: To investigate the immunomodulatory effects of vitamin D against the UC, and to explore the potential downstream mechanisms. Materials and methods: Serum vitamin ...  Read More

Association of Myeloperoxidase -463 G/A Polymorphism with Clinical Outcome of Helicobacter Pylori infection in Iranian Patients with Gastrointestinal Diseases

Eskandar Kamali-Sarvestani; Hadi Farsiani; Michel Shamoon Pour; Abdulah Bazargani; Kamran Lankarani; Ali-Reza Taghavi; Mehdi Saberifiroozi

Volume 4, Issue 3 , December 2007, , Pages 155-160

Abstract
  Background: Polymorphisms in the immune related genes are important in the clinical outcome of Helicobacter pylori infection. Myeloperoxidase -463 G/A polymorphism has been shown to reduce enzyme expression and activity. Objective: the aim of the present study is to investigate the association of myeloperoxidase ...  Read More

Production and Characterization of Monoclonal Antibody against Saffron Pollen Profilin, Cro s 2

Mojtaba Sankian; Forough Glosaze Shirazi; Mahid Arafi; Malihe Moghadam; Abdolreza Varasteh

Volume 5, Issue 3 , September 2008, , Pages 156-162

Abstract
  Background: Allergy to Saffron (Crocus sativus) pollen has been described in people involved in processing of saffron flower stamens. Profilins have been identified as a pan-allergen in different plant pollens and foods. This molecule is an actin-binding pro-tein with a molecular weight of 12-16 kDa ...  Read More

Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants

Zahra Amirghofran; Saeed Malek-Hosseini; Hossein Golmoghaddam; Fathollah Kalantar; Mehdi Shabani

Volume 8, Issue 3 , September 2011, , Pages 159-169

Abstract
  Background: A number of medicinal plants have been used to treat various immunological diseases. Nitric oxide (NO) has an important regulatory role in the various types of inflammatory processes. Objective: To investigate the NO modulatory activity of the extracts of several medicinal plants native to ...  Read More

Microchimerism and Renal Transplantation: Doubt Still Persists

Behrouz Nikbin; Nader Tajik; Ali Saraji; Gholam Reza Pourmand; Fatemeh Talebian; Abdurasul Mehrsai; Ali Akbar Amirzargar

Volume 1, Issue 3 , December 2004, , Pages 162-168

Abstract
  Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions ...  Read More

The Role of Zataria Multiflora Essence (Iranian herb) on Innate Immunity of Animal Model

Hojjatollah Shokri; Farzad Asadi; Ali Reza Bahonar; Ali Reza Khosravi

Volume 3, Issue 4 , December 2006, , Pages 164-168

Abstract
  Background: Herbal medicines have been used since ancient times for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity. Objective: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic ...  Read More

Optimizing Dendritic Cell Preparation for Fusion with Melanoma Cells

Yang Li; Lu Zhang; Shouyu Wang; Peng Shi; Wei Qu

Volume 11, Issue 3 , September 2014, , Pages 166-176

Abstract
  Background: Fusion of dendritic cells (DCs) with melanoma cells could reinforce the antigenicity of tumors as a strategy for the treatment of malignant melanoma. However, the insufficient quantity of DCs and the low fusion efficiency limits the development of such approach. Objective: To define the ...  Read More

Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice

Jianrong Niu; Hui Zhou; Rong Tian; Xudong Wang

Volume 20, Issue 2 , June 2023, , Pages 167-176

https://doi.org/10.22034/iji.2023.97283.2494

Abstract
  Background: Molecular markers are involved in atopic dermatitis (AD) pathogenesis. The estrogen receptor (ESR)-1 gene, encoding ERα, is reported to express aberrantly in AD patients.Objective: To detect the biological functions of ESR1 in 2,4 dinitrochlorobenzene (DNCB)-treated mice.Methods: The ...  Read More

Evaluation of the Immunomodulatory Effect of Curdlan on Maturation and Function of Mouse Spleen-Derived Dendritic Cells

Mohammad Hashem Soltani; Tahereh Kalantari; Mohammad Hossein Karimi; Nasrollah Erfani; Eskandar Kamali Sarvestani

Volume 9, Issue 3 , September 2012, , Pages 168-174

Abstract
  Background: T helper 1 and T helper 17 cells play important roles in immunity against foreign invaders. Differentiation of these Th subsets is affected by state of maturation and cytokines that are produced by dendritic cells (DCs). Curdlan is a linear (1→3)-β- glucan and has shown activity ...  Read More

Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model

Afshin Namdar; Hamid Reza Mirzaei; Farhad Jadidi-Niaragh; Mahboubeh Ashourpour; Maryam Ajami; Jamshid Hadjati; Abbas Rezaei

Volume 12, Issue 3 , September 2015, , Pages 176-187

Abstract
  Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid ...  Read More

Natural Killer Cell Cytotoxicity Against SKOV3 after HLA-G Downregulation by shRNA

Nazanin Nazari; Shirin Farjadian

Volume 13, Issue 3 , September 2016, , Pages 178-185

Abstract
  Background: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. Objective: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. Methods: ...  Read More

Mesenchymal Stem Cells Do Not Suppress Lymphoblastic Leukemic Cell Line Proliferation

Neda Mousavi Niri; Mansooreh Jaberipour; Mahboobeh Razmkhah; Abbas Ghaderi; Mojtaba Habibagahi

Volume 6, Issue 4 , December 2009, , Pages 186-194

Abstract
  Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived ...  Read More

Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome

Reza Amani; Amir Abbasnezhad; Eskandar Hajiani; Bahman Cheraghian; Zahra Abdoli; Razieh Choghakhori

Volume 15, Issue 3 , September 2018, , Pages 186-196

https://doi.org/10.22034/iji.2018.39388

Abstract
  Background: Given the variations in clinical presentation and physiopathological mechanisms in irritable bowel syndrome (IBS) subtypes, it is an acknowledged fact that the response to treatments can be disparate. Objective: To assess the effect of vitamin D on inflammatory cytokines (IL-17, IL-10, TNF-α), ...  Read More

The Regulation of the IL-18 on Group 2 Innate Lymphoid Cells in Allergic Rhinitis

Chuling Li; Yaxiong Xu; Xianglin Luo; Fajian Chen

Volume 18, Issue 3 , September 2021, , Pages 188-194

https://doi.org/10.22034/iji.2021.85982.1734

Abstract
  Background: Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation by producing interleukin-4 (IL-4), IL-5, IL-9, and IL-13. IL-18 can promote T helper 2 cell (Th2) response by inducing IL-4, and IL-13 production from mast cells and basophils. However, the regulation of IL-18 on ILC2s remained ...  Read More

Polyclonal Antibody against Different Extracellular Subdomains of HER2 Induces Tumor Growth Inhibition in vitro

Reza Hosseini-Ghatar; Tahereh Soltantoyeh; Motahareh Bahadori; Jalal Khoshnoodi; Forough Golsaz-Shirazi; Mahmood Jeddi-Tehrani; Mohammad Mehdi Amiri; Fazel Shokri

Volume 14, Issue 3 , September 2017, , Pages 200-214

Abstract
  Background: Human epidermal growth factor receptor 2 (HER2) has a crucial role in several malignancies. The extracellular domain of HER2 (HER2-ECD) has been extensively employed as an important target in passive and active immunotherapy. Isolated recombinant prokaryotic HER2-ECD subdomains were previously ...  Read More

Deficient Expression of Bruton's Tyrosine Kinase in Monocytes from X-Linked Agammaglobulinemia as Evaluated by a Flow Cytometric Analysis and its Clinical Application to Carrier Detection

Asghar Aghamohammadi; Ali Akbar Amirzargar; Nima Parvaneh; Paul Marjousef; Mostafa Moin; Abdolhassan Farhoudi; Mehdi Yeganeh; Toshio Miyawaki

Volume 2, Issue 4 , December 2005, , Pages 201-207

Abstract
  Background: The B-cell defect in X-linked agammaglobulinemia (XLA) is caused by mutations in the gene for Bruton's tyrosine kinase (BTK). BTK mutations result in deficient expression of BTK protein in peripheral blood monocytes. Methods: Using the anti-BTK monoclonal antibody (48-2H), a flow cytometric ...  Read More

Production and Characterization of a Monoclonal Antibody against an Antigen on the Surface of Non-Small Cell Carcinoma of the Lung

Sedigheh Sharifzadeh; Helmout Modjtahedi; Mahmood Jedi Tehrani; Abbas Ghaderi

Volume 4, Issue 4 , December 2007, , Pages 206-214

Abstract
  Background: Lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (NSCLC). For therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer. Objective: To charac-terize a murine monoclonal antibody (ME3D11) reactive ...  Read More