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Propylene-Glycol Aggravates LPS-Induced Sepsis through Production of TNF-α and IL-6

Annamaria Marton; Csongor Kolozsi; Erzsebet Kusz; Zoltan Olah; Tamas Letoha; Csaba Vizler; Laszlo Pecze

Volume 11, Issue 2 , June 2014, , Pages 113-122

Abstract
  Background : Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: ...  Read More