Firouz Pouralibaba; Zohreh Babaloo; Farzaneh Pakdel; Tahmoores Abdollahian; Solmaz Pourzare
Volume 9, Issue 4 , December 2012, , Pages 261-265
Abstract
Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients ...
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Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and exclusion criteria. Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data was analyzed using Student’s t-test for comparison of IL-23 levels between the two groups. Results: Mean serum levels of IL-23 in patients with pemphigus and healthy controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p<0.05). Conclusions: Based on the findings of this study, serum levels of IL-23 were higher in patients with pemphigus in comparison to healthy individuals with no clinical significance.