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Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes

Yolanda Cataño Cañizalez; Edith Uresti Rivera; Rocio Garcia Jacobo; Diana Portales Perez; Yadira Bastian; J Rodriguez Rivera; Roberto Gonzalez Amaro; Jose Enciso Moreno; Mariana Garcia Hernandez

Volume 15, Issue 2 , June 2018, , Pages 142-155

https://doi.org/10.22034/iji.2018.39378

Abstract
  Background: Chronic inflammation has critical role in Type 2 diabetes (T2D), in which IL-1β contributes in insulin resistance and beta cell dysfunction. The activation of NLRP3 and AIM2 by endogens ligands, such as mtDNA can lead to the release of active form of IL-1β. Objective: To evaluate ...  Read More