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1. LPS Activated Macrophages Induced Hepatocyte Pyroptosis via P2X7R Activation of NLRP3 in Mice

Lidan Luo; Yuan Fang; Qi Yuan; Jinmao Liao; Zheng Zhang

Volume 19, Issue 1 , March 2022, , Pages 37-48

http://dx.doi.org/10.22034/iji.2022.90579.2016

Abstract
  Background: Pyroptosis is a programmed cell death related to caspase-1, accompanied by the secretion of pro-inflammatory cytokines. Objectives: To explore the effects of LPS on the P2X7R/NLRP3 pathway in macrophages, and hepatocytes pyroptosis in mice. Methods: LPS was used to establish an animal ...  Read More