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Recombinant Production and One Step Purification of IL-1Ra in Escherichia coli and Evaluation its IL-1 Antagonizing Efficacy

Roya Adelnia; Fatemeh Shafiee

Volume 18, Issue 2 , June 2021, , Pages 141-149

https://doi.org/10.22034/iji.2021.89103.1929

Abstract
  Background: Anakinra (Kineret®), an IL-1 receptor antagonist, is the first FDA approved biologic drug for antagonizing IL-1 effects in patients with Rheumatoid arthritis. Notably, the less expensive production of this drug might help reduce the final therapeutic costs. Objectives: This study aimed ...  Read More