@article { author = {Sajedi Khania, Mahdi and Abdi Ardekan, Alireza and Khosropana, Shahdad and Doroudchi, Mehrnoosh}, title = {Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction}, journal = {Iranian Journal of Immunology}, volume = {13}, number = {2}, pages = {100-113}, year = {2016}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries. Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (AAMI) for developing cardiovascular accidents in a 6-month period. CCL5 and CCL18 levels were measured on admission, at day 5 and at day 180 posthospitalization. Results: CCL18 and CCL5 levels at day 180 were higher in patients with late (day 180) and early (day 5) LVEF less than 35% compared to those with higher LVEF (p=0.05 and p=0.042, respectively). There was a negative correlation between early and late LVEF and regional wall motion abnormalities (p=0.001 and p=0.002, respectively). There was also a trend of negative correlation between CCL18 levels at day 5 and LVEF levels at day 180 post-hospitalization (p=0.06). Conclusion: CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI.}, keywords = {Acute Anterior Myocardial Infarction,CCL5,CCL18,Ejection fraction}, url = {https://iji.sums.ac.ir/article_16661.html}, eprint = {https://iji.sums.ac.ir/article_16661_9314edc1bd18ecd51e016994e99b64a5.pdf} }