@article { author = {Babaloo, Zohreh and Khajir Yeganeh, Reza and Farhoodi, Mehdi and Baradaran, Behzad and Bonyadi, Mohamadreza and Aghebati, Leila}, title = {Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis}, journal = {Iranian Journal of Immunology}, volume = {10}, number = {1}, pages = {47-54}, year = {2013}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1). Objective: To identify the relative levels of IL-27 and IL-17A in MS disease. Method: In a case-control study, venous blood was collected from forty MS patients and forty-three healthy subjects as control group. Serum levels of IL-27 and IL-17A were measured by ELISA method. Results: A significant difference between serum IL-17A concentration in patients (120.68 ± 209.85 pg/ml) and control group (67.26 ± 117.76 pg/ml, p=0.016) was found. Serum IL-27 levels of the MS patients (159.7 ± 581.4 pg/ml) were significantly lower than control subjects (180.35 ± 507.84 pg/ml, p=0.001). Conclusion: Our findings show decreased levels of IL-27 against increasing IL-17A levels in patients group which may suggest the suppressive role of IL-27 on inflammatory process of MS.}, keywords = {Interleukin-27,Interleukin-17A,Multiple Sclerosis}, url = {https://iji.sums.ac.ir/article_16804.html}, eprint = {https://iji.sums.ac.ir/article_16804_e5d31f7680d680e678d2364ed27ab4c9.pdf} }