@article { author = {Biria, Mina and Sattari, Mandana and Golpayegani, Mojtaba Vahid and Kooshki, Fahimeh}, title = {Association of Salivary sCD14 Concentration Levels with Early Childhood Caries}, journal = {Iranian Journal of Immunology}, volume = {7}, number = {3}, pages = {193-197}, year = {2010}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Early childhood caries (ECC) is a severe type of dental caries affecting infants and pre-school children. Because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development. Objective: This study investigated the association between the presence of salivary sCD14 and ECC. Methods: This study was carried out on 40 healthy children, of whom 20 were caries-free (CF) and 20 had ECC, within the ages of 36 to 71 months. Unstimulated saliva of the children was collected with disposable needle-less syringe from buccal and labial vestibules. Seven children with ECC received complete treatments. Saliva was collected for a second time after 3 months from this group. The sCD14 levels in salivary samples were analyzed by ELISA method. Results: Mean concentrations of sCD14 in ECC and CF groups were 57.82 and 31.92 ng/ml respectively (p=0.008). After three months, the mean concentration of sCD14 among the treated children decreased to 11.38 ng/ml, which was significantly lower compared to that of ECC children before intervention (p<0.001), and also CF children (p<0.05). Conclusion: The increased levels of sCD14 can be considered as a marker of inflammation and innate immune response during ECC.}, keywords = {dental caries,Saliva,sCD14}, url = {https://iji.sums.ac.ir/article_17056.html}, eprint = {https://iji.sums.ac.ir/article_17056_b94f13ba6fde2a20d733678244b97a9e.pdf} }