@article { author = {Omrani, Mir Davood and Mokhtari, Mohammad Reza and Tagizadae, Ali and Bagheri, Morteza and Ahmad-Poor, Pedram}, title = {Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival}, journal = {Iranian Journal of Immunology}, volume = {5}, number = {4}, pages = {201-206}, year = {2008}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. Objective: The aim of current investigation was to study the impact of polymor-phisms of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I on renal allograft survival. Methods: Using PCR and PCR-RFLP methods in 84 renal transplant recipients, the influ-ence of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. Rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years. Results: Significant reductions were found in the risk of renal transplant rejection in recipients possessing the CCR2-64I (A) allele (p=0.03) or 59029-A allele (p=0.03) compared to non-rejector group. There were no significant differences in the fre-quency of CCR5Δ32 polymorphism in rejector group compared to non-rejector group (p>0.05). Conclusion: It was possible to conclude that the chemokine receptors CCR2-V64I (A) and CCR5- 59029 A alleles may influence renal allograft survival.}, keywords = {Chemokine Receptors,Genetic Polymorphism,Genotyping,Graft Re-jections,Graft Survival,renal transplantation}, url = {https://iji.sums.ac.ir/article_17168.html}, eprint = {https://iji.sums.ac.ir/article_17168_1066b530d3351e6f703eff7806258336.pdf} }