@article { author = {Mansouri, Reza and Akbari, Firoozeh and Vodjgani, Mohammad and Mahboudi, Fereidoun and Kalantar, Fathollah and Mirahmadian, Mahroo}, title = {Serum Cytokines Profiles in Iranian Patients with Preeclampsia}, journal = {Iranian Journal of Immunology}, volume = {4}, number = {3}, pages = {179-185}, year = {2007}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {}, abstract = {Background: Preeclampsia is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. Several studies have reported abnormal levels of cytokines in women with preeclampsia. Objectives: To detect serum levels of various cytokines in pregnant women with and without preeclampsia in the third trimester of pregnancy. Methods: Thirty patients with preeclampsia and thirty normal pregnant women were enrolled in the study. Blood samples were taken and serum levels of IFN γ, IL-12p70, IL-18, IL-15, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). Results: Preeclamptic women had significantly increased levels of circulating IL-12p70 (p < 0.05), IL-18 (p < 0.001), IL-4 (p < 0.001), IL-15 (p < 0.05) and IFN γ (p < 0.001). By contrast, circulating levels of IL-10 were not significantly different between the two groups. Conclusions: The present study supports the hypothesis of altered immune response in preeclampsia and suggests that dysregulation of cytokine expression occurs in preeclampsia with increased levels of IFN γ, IL-12p70, IL-15, IL-18 and IL-4.}, keywords = {Preeclampsia,Cytokines,ELISA}, url = {https://iji.sums.ac.ir/article_17196.html}, eprint = {https://iji.sums.ac.ir/article_17196_ed35a8f78cf7e1a971ec261796f5514f.pdf} }