@article { author = {Hadinia, Abolghasem and Doustimotlagh, Amir Hossein and Goodarzi, Hamed Reza and Arya, Arash and Jafarinia, Mojtaba}, title = {Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis}, journal = {Iranian Journal of Immunology}, volume = {16}, number = {4}, pages = {327-333}, year = {2019}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {10.22034/iji.2019.80284}, abstract = {Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1b, IL-6, and TNF-a were determined by ELISA, and biochemical parameters were measured using colorimetric methods. Results: IL-1b and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-a levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively). Conclusion: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.}, keywords = {Interleukin-1β,Interleukin-6,Non-Alcoholic Fatty Liver,Non-Alcoholic Steatohepatitis,Tumor Necrosis Factor-α}, url = {https://iji.sums.ac.ir/article_45975.html}, eprint = {https://iji.sums.ac.ir/article_45975_913f78d579803433d8794315c36d1e80.pdf} }