@article { author = {Hassani, Danesh and Amiri, Mohammad Mehdi and Maghsood, Faezeh and Salimi, Vahid and Kardar, Gholam Ali and Barati, Omid and Hashemian, Seyed Mohammad Reza and Jeddi-Tehrani, Mahmood and Zarnani, Amir-Hassan and Shokri, Fazel}, title = {Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?}, journal = {Iranian Journal of Immunology}, volume = {18}, number = {1}, pages = {47-53}, year = {2021}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {10.22034/iji.2021.87990.1843}, abstract = {Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. Objective: To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. Methods: The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Results: Our results revealed significant differences in anti-NP (p <0.0001) and anti-RBD (p <0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (p <0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (p <0.01). Conclusion: Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody.}, keywords = {Antibody Response,Cross-protection,MMR,SARS-CoV2,Tetanus}, url = {https://iji.sums.ac.ir/article_47467.html}, eprint = {https://iji.sums.ac.ir/article_47467_2866f9f848db52c513482a08052f27a2.pdf} }