@article { author = {Stojanovic, Maja and Andric, Zorana and Popadic, Dusan and Stankovic Stanojevic, Marija and Miskovic, Rada and Jovanovic, Dragana and Peric Popadic, Aleksandra and Bolpacic, Jasna and Tomic-Spiric, Vesna and Raskovic, Sanvila}, title = {Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis}, journal = {Iranian Journal of Immunology}, volume = {18}, number = {4}, pages = {354-365}, year = {2021}, publisher = {Shiraz Institute for Cancer Research}, issn = {1735-1383}, eissn = {1735-367X}, doi = {10.22034/iji.2021.88846.1911}, abstract = {Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic characteristics, and potential significance in prognosis. Methods: Twenty-five, unrelated TA patients were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, and the HLA-DQB1 loci. The frequencies of the HLA-A, HLA-B, and the HLA-DRB1 were compared with a control group of 1992, while the HLA-C and the HLA-DQB1 were compared with a group of 159 healthy, unrelated individuals. Results: Among TA patients, 5/25 (20%) were identified as the HLA-B*52 carriers. There was a significant difference in the HLA-B*52 allele frequency in the TA patients (10%) compared with the healthy controls (1.2%). Moreover, presence of the HLA-B*52 was associated with significantly earlier disease onset, more severe clinical presentations, and a poorer response to treatment. The HLA-C*03 was detected in 32% of patients and was present exclusively in those with a clinically mild form of the TA, indicating a putative protective effect. Conclusion: These findings indicate that the HLA-B*52 allele contributes to a higher susceptibility to the TA whereas the HLA-C*03, can be a protective factor in the TA.}, keywords = {Biomarkers,HLA,Immunogenetics,Takayasu arteritis,Vasculitis}, url = {https://iji.sums.ac.ir/article_48037.html}, eprint = {https://iji.sums.ac.ir/article_48037_4ea31aa46dba9f33a89bcfa50a592b98.pdf} }