%0 Journal Article %T Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients %J Iranian Journal of Immunology %I Shiraz Institute for Cancer Research %Z 1735-1383 %A Eyigor, Mete %A Eyigor, Hulya %A Osma, Ustun %A Yilmaz, MustafaDeniz %A Erin, Nuray %A Selcuk, Omer Tarik %A Sezer, Cem %A Gultekin, Meral %A Koksoy, Sadi %D 2014 %\ 12/01/2014 %V 11 %N 4 %P 259-268 %! Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients %K Bead Array %K Cytokine %K Dysplasia %K HNSCC %K Larynxm Carcinoma %R %X Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) levels. Additionally, IL-8 levels were determined through ELISA. Results: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p<0.05). IL-8 and IL-10 levels were also higher in SCC patients than dysplasia patients (p<0.05). Additionally, IL-6 and IL-10 were all found to be markedly increased in dysplasia patients compared with controls (p<0.05). Conclusion: Our results demonstrate an imbalance of IL-6 and IL-10 not only in HNSCC but also in laryngeal dysplasia. %U https://iji.sums.ac.ir/article_16786_c6e88da9f558d773a7abdfd40659951d.pdf