%0 Journal Article %T Age-Related Prostate Specific Antigen Reference Ranges in Healthy Northern Iranian Men %J Iranian Journal of Immunology %I Shiraz Institute for Cancer Research %Z 1735-1383 %A Rahimifar, Shahrzad %A Montazeri, Adel %D 2018 %\ 03/01/2018 %V 15 %N 1 %P 68-73 %! Age-Related Prostate Specific Antigen Reference Ranges in Healthy Northern Iranian Men %R %X Background: Prostate cancer is the third most common malignancy in men worldwide. Despite being a helpful biomarker in prostate cancer, prostate specific antigen (PSA) is affected by different factors including age, lifestyle, geographical region and ethnicity. Objective: To determine the age specific serum PSA level among healthy Northern Iranian men and to compare the results of our study with the findings of other populations in the world. Methods: A total of 1271 men who were referred for routine check-up in a multispecialty hospital in the city of Rasht, in Northern Iran, were evaluated for their PSA levels by commercial ELISA method. Results: The normal age related prostate specific antigen range (0-95th percentile) in our study was 0.0-0.62 in men younger than 40 yrs; 0.0-0.75 ng/ml in 40-49 yrs; 0.0-0.91 ng/ml in 50-59 yrs; 0.0-1.33 ng/ml in 60-69 yrs; 0.0-1.45 ng/ml in 70-79 yrs group and 0.0-1.93 in subjects older than 80 yrs. Conclusion: The present study revealed the lowest upper limit of PSA level in all age groups in comparison to populations from different countries. %U https://iji.sums.ac.ir/article_39342_c05a7105b54956ae9574616671bb88fa.pdf